TRPA1 - Transient receptor potential cation channel subfamily A member 1 - human protein (Function)
 
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Protein
Gene
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TRPA1 »  Transient receptor potential cation channel subfamily A member 1
 
Protein also known as:  Ankyrin-like with transmembrane domains protein 1.
Gene name:  TRPA1
Entry whose protein(s) existence is based on evidence at protein level
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1 120 1
GENE REF ISO

Function

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Overview 
Receptor-activated non-selective cation channel involved in detection of pain and possibly also in cold perception and inner ear function (PubMed25389312, PubMed25855297). Has a central role in the pain response to endogenous inflammatory mediators and to a diverse array of volatile irritants, such as mustard oil, cinnamaldehyde, garlic and acrolein, an irritant from tears gas and vehicule exhaust fumes (PubMed25389312, PubMed20547126). Is also activated by menthol (in vitro)(PubMed25389312). Acts also as a ionotropic cannabinoid receptor by being activated by delta(9)-tetrahydrocannabinol (THC), the psychoactive component of marijuana (PubMed25389312). May be a component for the mechanosensitive transduction channel of hair cells in inner ear, thereby participating in the perception of sounds. Probably operated by a phosphatidylinositol second messenger system (By similarity).  
5
  • UniProtKB
According to TCDB this is a transporter from family:
the transient receptor potential ca(2+) channel (trp-cc) family  1.A.4.6.3  
GO molecular function 
Channel activitydefinition[GO:0015267]  
1
  • PINC
Intracellular ligand-gated calcium channel activitydefinition[GO:0005218]  
2
  • UniProtKB
Temperature-gated cation channel activitydefinition[GO:0097604]  
1
  • UniProtKB
GO biological process 
Calcium ion transmembrane transportdefinition[GO:0070588]  
2
  • UniProtKB
Cell surface receptor signaling pathwaydefinition[GO:0007166] silver  
1
  • Ortholog Compara
Detection of chemical stimulus involved in sensory perception of paindefinition[GO:0050968] silver  
1
  • Ortholog Compara
Detection of mechanical stimulus involved in sensory perception of paindefinition[GO:0050966] silver  
1
  • Ortholog Compara
Ion transportdefinition[GO:0006811]  
1
  • PINC
Protein homotetramerizationdefinition[GO:0051289]  
1
  • UniProtKB
Response to colddefinition[GO:0009409] silver  
1
  • Ortholog Compara
Response to drugdefinition[GO:0042493] silver  
1
  • Ortholog Compara
Response to hydrogen peroxidedefinition[GO:0042542] silver  
1
  • Ortholog Compara
Response to organic cyclic compounddefinition[GO:0014070] silver  
1
  • Ortholog Compara
Response to organic substancedefinition[GO:0010033]  
1
  • UniProtKB
Response to paindefinition[GO:0048265] silver  
1
  • Ortholog Compara
Sensory perception of paindefinition[GO:0019233]  
1
  • UniProtKB
Thermoceptiondefinition[GO:0050955] silver  
1
  • Ortholog Compara
Enzymatic activity 
It is regulated in the following manner
Inhibited by ruthenium red, a potent blocker of TRPV channels.  
2
  • UniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathway:
TRP channels  R-HSA-3295583  
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Sensory transduction  definition   [KW-0716]
Transport  definition   [KW-0813]
Molecular function 
Ion channel  definition   [KW-0407]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GenomeRNAi: 8989
PRO: PR:O75762
Chemistry
GuidetoPHARMACOLOGY: 485