TRPA1 - Transient receptor potential cation channel subfamily A member 1 - human protein (Function)
 
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TRPA1 »  Transient receptor potential cation channel subfamily A member 1
 
Protein also known as:  Ankyrin-like with transmembrane domains protein 1.
Gene name:  TRPA1
Entry whose protein(s) existence is based on evidence at protein level
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1 89 1
GENE REF ISO

Function

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Overview 
Receptor-activated non-selective cation channel involved in detection of pain and possibly also in cold perception and inner ear function. Has a central role in the pain response to endogenous inflammatory mediators and to a diverse array of volatile irritants, such as mustard oil, garlic and acrolein, an irritant from tears gas and vehicule exhaust fumes. Acts also as a ionotropic cannabinoid receptor by being activated by delta(9)-tetrahydrocannabinol (THC), the psychoactive component of marijuana. Not involved in menthol sensation. May be a component for the mechanosensitive transduction channel of hair cells in inner ear, thereby participating in the perception of sounds. Probably operated by a phosphatidylinositol second messenger system (By similarity).  
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the transient receptor potential ca(2+) channel (trp-cc) family  1.A.4.6.3  
GO molecular function 
Calcium channel activitydefinition[GO:0005262] silver  
  • IEAOrtholog Compara
Channel activitydefinition[GO:0015267]  
1
  • TASPINC
GO biological process 
Detection of chemical stimulus involved in sensory perception of paindefinition[GO:0050968] silver  
  • IEAOrtholog Compara
Detection of mechanical stimulus involved in sensory perception of paindefinition[GO:0050966] silver  
  • IEAOrtholog Compara
Ion transportdefinition[GO:0006811]  
1
  • TASPINC
Response to colddefinition[GO:0009409] silver  
  • IEAOrtholog Compara
Response to drugdefinition[GO:0042493] silver  
  • IEAOrtholog Compara
Response to hydrogen peroxidedefinition[GO:0042542] silver  
  • IEAOrtholog Compara
Response to paindefinition[GO:0048265] silver  
  • IEAOrtholog Compara
Thermoceptiondefinition[GO:0050955] silver  
  • IEAOrtholog Compara
Enzymatic activity 
It is regulated in the following manner
Inhibited by ruthenium red, a potent blocker of TRPV channels (By similarity).  
  • CuratedUniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathway:
TRP channels  REACT_169333  
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Sensory transduction  definition   [KW-0716]
Transport  definition   [KW-0813]
Molecular function 
Ion channel  definition   [KW-0407]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GenomeRNAi: 8989
PRO: PR:O75762
Chemistry
GuidetoPHARMACOLOGY: 485