RAD51D - DNA repair protein RAD51 homolog 4 - human protein (Function)
 
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Protein
Gene
References

 
RAD51D »  DNA repair protein RAD51 homolog 4
 
Protein also known as:  RAD51-like protein 3.
Gene name:  RAD51D
Family name: RecA » RAD51
Entry whose protein(s) existence is based on evidence at protein level
extend overview
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GENE REF ISO

Function

 show evidences
Overview 
Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. Bind to single-stranded DNA (ssDNA) and has DNA-dependent ATPase activity. Part of the Rad21 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. Involved in telomere maintenance. The BCDX2 subcomplex XRCC2:RAD51D can stimulate Holliday junction resolution by BLM.  
8
  • UniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • UniProtKB KW
DNA bindingdefinition[GO:0003677]  
1
  • PINC
DNA-dependent ATPase activitydefinition[GO:0008094]  
1
  • UniProtKB
Double-stranded DNA bindingdefinition[GO:0003690]  
1
  • RefGenome
Contributes to endodeoxyribonuclease activitydefinition[GO:0004520]  
1
  • RefGenome
Contributes to four-way junction DNA bindingdefinition[GO:0000400]  
1
  • UniProtKB
Gamma-tubulin bindingdefinition[GO:0043015]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
10
  • IntAct
Recombinase activitydefinition[GO:0000150]  
1
  • RefGenome
Single-stranded DNA bindingdefinition[GO:0003697]  
1
  • UniProtKB
GO biological process 
Double-strand break repair via homologous recombinationdefinition[GO:0000724]  
1
  • UniProtKB
Interstrand cross-link repairdefinition[GO:0036297] silver  
1
  • Ortholog Compara
Meiotic DNA recombinase assemblydefinition[GO:0000707]  
1
  • RefGenome
Mitotic recombinationdefinition[GO:0006312]  
1
  • RefGenome
Nucleotide-excision repairdefinition[GO:0006289] silver  
1
  • Ortholog Compara
Reciprocal meiotic recombinationdefinition[GO:0007131]  
1
  • PINC
Regulation of cell cycledefinition[GO:0051726] silver  
1
  • Ortholog Compara
Response to ionizing radiationdefinition[GO:0010212]  
1
  • RefGenome
Strand invasiondefinition[GO:0042148]  
1
  • UniProtKB
Telomere maintenancedefinition[GO:0000723]  
1
  • UniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathway:
Homologous recombination  hsa03440+5892  
According to Reactome, this protein belongs to the following pathways:
HDR through Homologous Recombination (HRR)  R-HSA-5685942  
Homologous DNA Pairing and Strand Exchange  R-HSA-5693579  
Presynaptic phase of homologous DNA pairing and strand exchange  R-HSA-5693616  
Resolution of D-loop Structures through Holliday Junction Intermediates  R-HSA-5693568  
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)  R-HSA-5693554  
 

Keywords

Biological process 
DNA damage  definition   [KW-0227]
DNA recombination  definition   [KW-0233]
DNA repair  definition   [KW-0234]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: RAD51L3
GenomeRNAi: 5892
PRO: PR:O75771