ATP6AP2 - Renin receptor - human protein (Function)
 
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ATP6AP2 »  Renin receptor
 
Protein also known as:  Vacuolar ATP synthase membrane sector-associated protein M8-9 (ATP6M8-9).
Gene name:  ATP6AP2
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Functions as a renin and prorenin cellular receptor. May mediate renin-dependent cellular responses by activating ERK1 and ERK2. By increasing the catalytic efficiency of renin in AGT/angiotensinogen conversion to angiotensin I, it may also play a role in the renin-angiotensin system (RAS).  
1
  • CuratedUniProtKB
GO molecular function 
Enzyme bindingdefinition[GO:0019899] silver  
  • IEAOrtholog Compara
Protein bindingdefinition[GO:0005515]  
2
  • IPIUniProtKB
  • IPIHGNC
Receptor activitydefinition[GO:0004872] silver  
  • IEAInterPro 2 GO
GO biological process 
Angiotensin maturationdefinition[GO:0002003]  
2
  • IDAHGNC
Cell deathdefinition[GO:0008219]  
  • IEAUniProtKB KW
Eye pigmentationdefinition[GO:0048069]  
1
  • IMPUniProtKB
Head morphogenesisdefinition[GO:0060323]  
1
  • IMPUniProtKB
Positive regulation of transforming growth factor beta1 productiondefinition[GO:0032914]  
1
  • IDAHGNC
Positive regulation of Wnt signaling pathwaydefinition[GO:0030177]  
1
  • IMPUniProtKB
Regulation of MAPK cascadedefinition[GO:0043408]  
2
  • IDAHGNC
Rostrocaudal neural tube patterningdefinition[GO:0021903]  
1
  • IMPUniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathway:
Metabolism of Angiotensinogen to Angiotensins  REACT_147707  
 
More information is available from:
 

Keywords

Molecular function 
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ATP6AP2
GenomeRNAi: 10159
PRO: PR:O75787