GRAP2 - GRB2-related adapter protein 2 - human protein (Function)
 
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Protein
Gene
References

 
GRAP2 »  GRB2-related adapter protein 2
 
Protein also known as:  Hematopoietic cell-associated adapter protein GrpL.
Gene name:  GRAP2
Family name: GRB2/sem-5/DRK
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 61 2
GENE REF ISO

Function

 show evidences
Overview 
Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc.  
1
  • UniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
14
  • IntAct
  • HGNC
SH3/SH2 adaptor activitydefinition[GO:0005070]  
1
  • PINC
GO biological process 
Cell-cell signalingdefinition[GO:0007267]  
1
  • PINC
Positive regulation of signal transductiondefinition[GO:0009967]  
1
  • GOC
Ras protein signal transductiondefinition[GO:0007265]  
1
  • PINC
Pathways 
According to KEGG, this protein belongs to the following pathway:
T cell receptor signaling pathway  hsa04660+9402  
According to Reactome, this protein belongs to the following pathways:
CD28 co-stimulation  R-HSA-389356  
DAP12 signaling  R-HSA-2424491  
FCERI mediated Ca+2 mobilization  R-HSA-2871809  
FCERI mediated MAPK activation  R-HSA-2871796  
Generation of second messenger molecules  R-HSA-202433  
Signaling by SCF-KIT  R-HSA-1433557  
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: GRAP2
GenomeRNAi: 9402
PRO: PR:O75791