RNASEH2A - Ribonuclease H2 subunit A - human protein (Function)
 
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RNASEH2A »  Ribonuclease H2 subunit A   [ EC 3.1.26.4 ]  (RNase H2 subunit A)
 
Protein also known as:  Aicardi-Goutieres syndrome 4 protein (AGS4).
Gene name:  RNASEH2A
Family name: RNase HII » Eukaryotic
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Catalytic subunit of RNase HII, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.  
2
  • CuratedUniProtKB
GO molecular function 
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Ribonuclease activitydefinition[GO:0004540]  
1
  • TASPINC
RNA bindingdefinition[GO:0003723] silver  
  • IEAInterPro 2 GO
RNA-DNA hybrid ribonuclease activitydefinition[GO:0004523]  
1
  • IDAUniProtKB
GO biological process 
DNA replicationdefinition[GO:0006260]  
1
  • TASUniProtKB
Mismatch repairdefinition[GO:0006298]  
1
  • IDAMGI
RNA catabolic processdefinition[GO:0006401]  
1
  • IDAUniProtKB
RNA phosphodiester bond hydrolysisdefinition[GO:0090501]  
1
  • TASGOC
RNA phosphodiester bond hydrolysis, endonucleolyticdefinition[GO:0090502]  
1
  • IDAGOC
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.1.26.4: Endonucleolytic cleavage to 5'-phosphomonoester.  
1
  • CuratedUniProtKB
It requires the following cofactor
Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding (By similarity).  
1
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathway:
DNA replication  hsa03030+10535  
 

Keywords

Molecular function 
Endonuclease  definition   [KW-0255]
Hydrolase  definition   [KW-0378]
Nuclease  definition   [KW-0540]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: RNASEH2A
GenomeRNAi: 10535
PRO: PR:O75792