BCAR3 - Breast cancer anti-estrogen resistance protein 3 - human protein (Function)
 
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BCAR3 »  Breast cancer anti-estrogen resistance protein 3
 
Protein also known as:  SH2 domain-containing protein 3B.
Gene name:  BCAR3
Entry whose protein(s) existence is based on evidence at protein level
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1 40 3
GENE REF ISO

Function

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Overview 
May act as an adapter protein and couple activated growth factor receptors to a signaling pathway that regulates the proliferation in breast cancer cells. When overexpressed, it confers anti-estrogen resistance in breast cancer cell lines. May also be regulated by cellular adhesion to extracellular matrix proteins.  
1
  • CuratedUniProtKB
GO molecular function 
Guanyl-nucleotide exchange factor activitydefinition[GO:0005085]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
2
  • IPIIntAct
GO biological process 
Positive regulation of GTPase activitydefinition[GO:0043547]  
  • IEAUniProtKB KW
  • IEAInterPro 2 GO
Response to drugdefinition[GO:0042493]  
1
  • TASPINC
Signal transductiondefinition[GO:0007165]  
1
  • TASPINC
Small GTPase mediated signal transductiondefinition[GO:0007264] silver  
  • IEAInterPro 2 GO
 

Keywords

Molecular function 
Guanine-nucleotide releasing factor  definition   [KW-0344]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: BCAR3
GenomeRNAi: 8412
PRO: PR:O75815