EIF3G - Eukaryotic translation initiation factor 3 subunit G - human protein (Function)
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EIF3G »  Eukaryotic translation initiation factor 3 subunit G  (eIF3g)
Protein also known as:  Eukaryotic translation initiation factor 3 RNA-binding subunit (eIF-3 RNA-binding subunit).
Gene name:  EIF3G
Family name: eIF-3 subunit G
Entry whose protein(s) existence is based on evidence at protein level
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Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. This subunit can bind 18S rRNA.  
  • CuratedUniProtKB
GO molecular function 
Nucleotide bindingdefinition[GO:0000166] silver  
  • IEAInterPro 2 GO
Poly(A) RNA bindingdefinition[GO:0044822]  
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
  • IPIIntAct
Contributes to translation initiation factor activitydefinition[GO:0003743]  
  • ICUniProtKB
GO biological process 
Formation of translation preinitiation complexdefinition[GO:0001731]  
  • IEAUniProtKB Annot
Regulation of translational initiationdefinition[GO:0006446]  
  • IEAUniProtKB Annot
Translational initiationdefinition[GO:0006413]  
  • ICUniProtKB
According to KEGG, this protein belongs to the following pathway:
RNA transport  hsa03013+8666  
According to Reactome, this protein belongs to the following pathways:
Formation of a pool of free 40S subunits  REACT_1797  
Formation of the ternary complex, and subsequently, the 43S complex  REACT_1079  
GTP hydrolysis and joining of the 60S ribosomal subunit  REACT_2085  
L13a-mediated translational silencing of Ceruloplasmin expression  REACT_79  
Ribosomal scanning and start codon recognition  REACT_931  
Translation initiation complex formation  REACT_1979  


Biological process 
Protein biosynthesis  definition   [KW-0648]
Molecular function 
Initiation factor  definition   [KW-0396]
Technical term 
Reference proteome  definition   [KW-1185]

Further external links

GeneWiki: EIF3G
GenomeRNAi: 8666
PRO: PR:O75821