IDH1 - Isocitrate dehydrogenase [NADP] cytoplasmic - human protein (Function)
 
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IDH1 »  Isocitrate dehydrogenase [NADP] cytoplasmic   [ EC 1.1.1.42 ]  (IDH)
 
Protein also known as:  Cytosolic NADP-isocitrate dehydrogenase.
Gene name:  IDH1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 358 1
GENE REF ISO

Function

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GO molecular function 
Isocitrate dehydrogenase (NADP+) activitydefinition[GO:0004450]  
3
  • IDAUniProtKB
Magnesium ion bindingdefinition[GO:0000287]  
1
  • IDAUniProtKB
NAD bindingdefinition[GO:0051287] silver  
  • IEAInterPro 2 GO
NADP bindingdefinition[GO:0050661] silver  
  • IEAOrtholog Compara
Protein homodimerization activitydefinition[GO:0042803]  
1
  • IPIUniProtKB
Receptor bindingdefinition[GO:0005102]  
1
  • IPIUniProtKB
GO biological process 
2-oxoglutarate metabolic processdefinition[GO:0006103]  
1
  • IDAUniProtKB
Female gonad developmentdefinition[GO:0008585] silver  
  • IEAOrtholog Compara
Glutathione metabolic processdefinition[GO:0006749] silver  
  • IEAOrtholog Compara
Glyoxylate cycledefinition[GO:0006097]  
  • IEAUniProtKB KW
Isocitrate metabolic processdefinition[GO:0006102]  
3
  • IDAUniProtKB
Response to oxidative stressdefinition[GO:0006979] silver  
  • IEAOrtholog Compara
Response to steroid hormonedefinition[GO:0048545] silver  
  • IEAOrtholog Compara
Tricarboxylic acid cycledefinition[GO:0006099]  
  • IEAUniProtKB KW
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 1.1.1.42: Isocitrate + NADP(+) 2-oxoglutarate + CO(2) + NADPH.  
1
  • CuratedUniProtKB
It requires the following cofactor
Binds 1 magnesium or manganese ion per subunit.  
1
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Citrate cycle (TCA cycle)  hsa00020+3417  
Glutathione metabolism  hsa00480+3417  
Metabolic pathways  hsa01100+3417  
Peroxisome  hsa04146+3417  
According to Reactome, this protein belongs to the following pathways:
Disease  REACT_116125  
Metabolism  REACT_111217  
 
More information is available from:
 

Biophysicochemical properties

Kinetic parameters
KM 49 uM for NADP
KM 65 uM for isocitrate
KM 29 uM for magnesium chloride

Keywords

Biological process 
Glyoxylate bypass  definition   [KW-0329]
Tricarboxylic acid cycle  definition   [KW-0816]
Molecular function 
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: O75874
Other
GeneWiki: IDH1
GenomeRNAi: 3417
PRO: PR:O75874