DGAT1 - Diacylglycerol O-acyltransferase 1 - human protein (Function)
 
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Protein
Gene
References

 
DGAT1 »  Diacylglycerol O-acyltransferase 1
 
Gene name:  DGAT1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 34 1
GENE REF ISO

Function

 show evidences
Overview 
Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. In contrast to DGAT2 it is not essential for survival. May be involved in VLDL (very low density lipoprotein) assembly. In liver, plays a role in esterifying exogenous fatty acids to glycerol. Functions as the major acyl-CoA retinol acyltransferase (ARAT) in the skin, where it acts to maintain retinoid homeostasis and prevent retinoid toxicity leading to skin and hair disorders.  
  • CuratedUniProtKB
GO molecular function 
2-acylglycerol O-acyltransferase activitydefinition[GO:0003846] silver  
  • IEAOrtholog Compara
Diacylglycerol O-acyltransferase activitydefinition[GO:0004144]  
1
  • IDAMGI
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
Retinol O-fatty-acyltransferase activitydefinition[GO:0050252]  
  • IEAEC 2 GO
Transferase activity, transferring acyl groupsdefinition[GO:0016746]  
1
  • TASPINC
GO biological process 
Diacylglycerol metabolic processdefinition[GO:0046339]  
  • ISSOrtholog Curator
Fatty acid homeostasisdefinition[GO:0055089] silver  
  • IEAOrtholog Compara
Lipid storagedefinition[GO:0019915]  
  • ISSOrtholog Curator
Long-chain fatty-acyl-CoA metabolic processdefinition[GO:0035336]  
  • ISSOrtholog Curator
Retinol metabolic processdefinition[GO:0042572]  
  • IEAEC 2 GO
Triglyceride biosynthetic processdefinition[GO:0019432]  
2
  • IDAMGI
  • IDAUniProtKB
Triglyceride metabolic processdefinition[GO:0006641]  
1
  • TASPINC
Very-low-density lipoprotein particle assemblydefinition[GO:0034379]  
1
  • IMPBHF-UCL
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reactions
EC 2.3.1.20: Acyl-CoA + 1,2-diacylglycerol CoA + triacylglycerol.  
1
  • CuratedUniProtKB
EC 2.3.1.76: Acyl-CoA + retinol CoA + retinyl ester.  
1
  • CuratedUniProtKB
It is regulated in the following manner
XP620 is a selective DGAT1 inhibitor.  
1
  • CuratedUniProtKB
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Fat digestion and absorption  hsa04975+8694  
Glycerolipid metabolism  hsa00561+8694  
Metabolic pathways  hsa01100+8694  
Retinol metabolism  hsa00830+8694  
According to Reactome, this protein belongs to the following pathways:
Acyl chain remodeling of DAG and TAG  REACT_121122  
Triglyceride Biosynthesis  REACT_1190  
 

Biophysicochemical properties

Kinetic parameters
KM 13.9 uM for palmitoyl coenzyme A
KM 25.9 uM for retinol

Keywords

Molecular function 
Acyltransferase  definition   [KW-0012]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 8694
PRO: PR:O75907