DHRS3 - Short-chain dehydrogenase/reductase 3 - human protein (Function)
 
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DHRS3 »  Short-chain dehydrogenase/reductase 3   [ EC 1.1.1.300 ]
 
Protein also known as:  Short chain dehydrogenase/reductase family 16C member 1.
Gene name:  DHRS3
Entry whose protein(s) existence is based on evidence at protein level
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1 21 2
GENE REF ISO

Function

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Overview 
Catalyzes the reduction of all-trans-retinal to all-trans-retinol in the presence of NADPH.  
2
  • UniProtKB
GO molecular function 
Electron carrier activitydefinition[GO:0009055]  
1
  • UniProtKB
NADP-retinol dehydrogenase activitydefinition[GO:0052650]  
1
  • EC 2 GO
Nucleotide bindingdefinition[GO:0000166]  
1
  • PINC
Retinol dehydrogenase activitydefinition[GO:0004745] silver  
1
  • Ortholog Compara
GO biological process 
Bone morphogenesisdefinition[GO:0060349] silver  
1
  • Ortholog Compara
Cardiac septum morphogenesisdefinition[GO:0060411] silver  
1
  • Ortholog Compara
Negative regulation of retinoic acid receptor signaling pathwaydefinition[GO:0048387] silver  
1
  • Ortholog Compara
Outflow tract morphogenesisdefinition[GO:0003151] silver  
1
  • Ortholog Compara
Oxidation-reduction processdefinition[GO:0055114]  
1
  • UniProtKB KW
Palate developmentdefinition[GO:0060021] silver  
1
  • Ortholog Compara
Regulation of ossificationdefinition[GO:0030278] silver  
1
  • Ortholog Compara
Retinol metabolic processdefinition[GO:0042572]  
1
  • UniProtKB
Visual perceptiondefinition[GO:0007601]  
1
  • PINC
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 1.1.1.300: All-trans-retinol + NADP(+) all-trans-retinal + NADPH.  
1
  • UniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Metabolic pathways  hsa01100+9249  
Retinol metabolism  hsa00830+9249  
According to Reactome, this protein belongs to the following pathways:
RA biosynthesis pathway  REACT_268561  
The retinoid cycle in cones (daylight vision)  REACT_160083  
 
More information is available from:
Note 
Located in a region of chromosome 1 which is often deleted in aggressive neuroblastoma tumors.  
1
  • UniProtKB
 

Keywords

Molecular function 
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: DHRS3
GenomeRNAi: 9249
PRO: PR:O75911