DHRS3 - Short-chain dehydrogenase/reductase 3 - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
DHRS3 »  Short-chain dehydrogenase/reductase 3   [ EC 1.1.1.300 ]
 
Protein also known as:  Retinal short-chain dehydrogenase/reductase 1 (retSDR1).
Gene name:  DHRS3
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 19 2
GENE REF ISO

Function

 show evidences
Overview 
Catalyzes the reduction of all-trans-retinal to all-trans-retinol in the presence of NADPH.  
1
  • CuratedUniProtKB
GO molecular function 
Electron carrier activitydefinition[GO:0009055]  
1
  • TASUniProtKB
NADP-retinol dehydrogenase activitydefinition[GO:0052650]  
  • IEAEC 2 GO
Nucleotide bindingdefinition[GO:0000166]  
1
  • TASPINC
GO biological process 
Retinol metabolic processdefinition[GO:0042572]  
1
  • TASUniProtKB
Visual perceptiondefinition[GO:0007601]  
1
  • TASPINC
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 1.1.1.300: All-trans-retinol + NADP(+) all-trans-retinal + NADPH.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Metabolic pathways  hsa01100+9249  
Retinol metabolism  hsa00830+9249  
According to Reactome, this protein belongs to the following pathways:
Disease  REACT_116125  
Signal Transduction  REACT_111102  
 
More information is available from:
Note 
Located in a region of chromosome 1 which is often deleted in aggressive neuroblastoma tumors.  
  • CuratedUniProtKB
 

Keywords

Molecular function 
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: DHRS3
GenomeRNAi: 9249
PRO: PR:O75911