PAK3 - Serine/threonine-protein kinase PAK 3 - human protein (Function)
 
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PAK3 »  Serine/threonine-protein kinase PAK 3   [ EC 2.7.11.1 ]
 
Protein also known as:  p21-activated kinase 3 (PAK-3).
Gene name:  PAK3
Entry whose protein(s) existence is based on evidence at protein level
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1 39 4
GENE REF ISO

Function

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Overview 
Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Additionally, phosphorylates TNNI3/troponin I to modulate calcium sensitivity and relaxation kinetics of thin myofilaments. May also be involved in early neuronal development.  
1
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
MAP kinase kinase activitydefinition[GO:0004708]  
1
  • IDAUniProtKB
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
2
  • IPIIntAct
Protein serine/threonine kinase activitydefinition[GO:0004674]  
  • IEAUniProtKB KW
Rho GTPase bindingdefinition[GO:0017048] silver  
  • IEAOrtholog Compara
SH3 domain bindingdefinition[GO:0017124]  
  • IEAUniProtKB KW
GO biological process 
Activation of MAPK activitydefinition[GO:0000187]  
1
  • IDAGOC
Axonogenesisdefinition[GO:0007409]  
  • ISSOrtholog Curator
Dendrite developmentdefinition[GO:0016358]  
  • ISSOrtholog Curator
Dendritic spine morphogenesisdefinition[GO:0060997]  
1
  • TASUniProtKB
MAPK cascadedefinition[GO:0000165]  
1
  • IDAGOC
Protein phosphorylationdefinition[GO:0006468] silver  
  • IEAInterPro 2 GO
Regulation of actin filament polymerizationdefinition[GO:0030833]  
1
  • IDAUniProtKB
Signal transduction by phosphorylationdefinition[GO:0023014] silver  
  • IBARefGenome
Synapse organizationdefinition[GO:0050808]  
1
  • TASUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.1: ATP + a protein ADP + a phosphoprotein.  
  • CuratedUniProtKB
It requires the following cofactor
Magnesium (By similarity).  
  • CuratedUniProtKB
It is regulated in the following manner
Activated by binding small G proteins. Binding of GTP-bound CDC42 or RAC1 to the autoregulatory region releases monomers from the autoinhibited dimer, enables phosphorylation of Thr-436 and allows the kinase domain to adopt an active structure (By similarity).  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Axon guidance  hsa04360+5063  
ErbB signaling pathway  hsa04012+5063  
Focal adhesion  hsa04510+5063  
Regulation of actin cytoskeleton  hsa04810+5063  
Renal cell carcinoma  hsa05211+5063  
T cell receptor signaling pathway  hsa04660+5063  
According to Reactome, this protein belongs to the following pathway:
Activation of Rac  REACT_19226  
 

Keywords

Molecular function 
Developmental protein  definition   [KW-0217]
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Allosteric enzyme  definition   [KW-0021]
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: PAK3
GenomeRNAi: 5063
PRO: PR:O75914
Chemistry
GuidetoPHARMACOLOGY: 2135