PAK3 - Serine/threonine-protein kinase PAK 3 - human protein (Function)
 
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PAK3 »  Serine/threonine-protein kinase PAK 3   [ EC 2.7.11.1 ]
 
Protein also known as:  p21-activated kinase 3 (PAK-3).
Gene name:  PAK3
Entry whose protein(s) existence is based on evidence at protein level
extend overview
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GENE REF ISO

Function

 show evidences
Overview 
Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Additionally, phosphorylates TNNI3/troponin I to modulate calcium sensitivity and relaxation kinetics of thin myofilaments. May also be involved in early neuronal development.  
2
  • UniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • UniProtKB KW
MAP kinase kinase activitydefinition[GO:0004708]  
1
  • UniProtKB
Metal ion bindingdefinition[GO:0046872]  
1
  • UniProtKB KW
Protein bindingdefinition[GO:0005515]  
2
  • IntAct
Protein serine/threonine kinase activitydefinition[GO:0004674]  
1
  • RefGenome
Rac GTPase bindingdefinition[GO:0048365]  
1
  • RefGenome
SH3 domain bindingdefinition[GO:0017124]  
1
  • UniProtKB KW
GO biological process 
Actin cytoskeleton organizationdefinition[GO:0030036]  
1
  • RefGenome
Activation of MAPK activitydefinition[GO:0000187]  
1
  • GOC
Axonogenesisdefinition[GO:0007409]  
1
  • Ortholog Curator
Cell migrationdefinition[GO:0016477]  
1
  • RefGenome
Cellular response to organic cyclic compounddefinition[GO:0071407] silver  
1
  • Ortholog Compara
Dendrite developmentdefinition[GO:0016358]  
1
  • Ortholog Curator
Dendritic spine morphogenesisdefinition[GO:0060997]  
1
  • UniProtKB
MAPK cascadedefinition[GO:0000165]  
1
  • GOC
Positive regulation of dendritic spine morphogenesisdefinition[GO:0061003] silver  
1
  • Ortholog Compara
Positive regulation of DNA biosynthetic processdefinition[GO:2000573] silver  
1
  • Ortholog Compara
Positive regulation of neuron apoptotic processdefinition[GO:0043525] silver  
1
  • Ortholog Compara
Regulation of actin filament polymerizationdefinition[GO:0030833]  
1
  • UniProtKB
Regulation of apoptotic processdefinition[GO:0042981]  
1
  • RefGenome
Regulation of mitotic cell cycledefinition[GO:0007346]  
1
  • RefGenome
Rho protein signal transductiondefinition[GO:0007266]  
1
  • RefGenome
Stress-activated protein kinase signaling cascadedefinition[GO:0031098]  
1
  • RefGenome
Synapse organizationdefinition[GO:0050808]  
1
  • UniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.1: ATP + a protein ADP + a phosphoprotein.  
1
  • UniProtKB
It requires the following cofactor
 Mg(2+)  
1
  • UniProtKB
It is regulated in the following manner
Activated by binding small G proteins. Binding of GTP-bound CDC42 or RAC1 to the autoregulatory region releases monomers from the autoinhibited dimer, enables phosphorylation of Thr-436 and allows the kinase domain to adopt an active structure (By similarity).  
1
  • UniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Axon guidance  hsa04360+5063  
ErbB signaling pathway  hsa04012+5063  
Focal adhesion  hsa04510+5063  
Regulation of actin cytoskeleton  hsa04810+5063  
Renal cell carcinoma  hsa05211+5063  
T cell receptor signaling pathway  hsa04660+5063  
According to Reactome, this protein belongs to the following pathways:
Activation of Rac  R-HSA-428540  
CD209 (DC-SIGN) signaling  R-HSA-5621575  
CD28 dependent Vav1 pathway  R-HSA-389359  
Ephrin signaling  R-HSA-3928664  
Generation of second messenger molecules  R-HSA-202433  
MAPK6/MAPK4 signaling  R-HSA-5687128  
RHO GTPases activate PAKs  R-HSA-5627123  
Sema3A PAK dependent Axon repulsion  R-HSA-399954  
VEGFR2 mediated vascular permeability  R-HSA-5218920  
 

Keywords

Molecular function 
Developmental protein  definition   [KW-0217]
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Allosteric enzyme  definition   [KW-0021]
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: PAK3
GenomeRNAi: 5063
PRO: PR:O75914
Chemistry
GuidetoPHARMACOLOGY: 2135