DYSF - Dysferlin - human protein (Function)
 
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Protein
Gene
References

 
DYSF »  Dysferlin
 
Protein also known as:  Dystrophy-associated fer-1-like protein.
Gene name:  DYSF
Family name: Ferlin
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Key calcium ion sensor involved in the Ca(2+)-triggered synaptic vesicle-plasma membrane fusion. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress (By similarity).  
1
  • UniProtKB
According to TCDB this is a transporter from family:
the synaptosomal vesicle fusion pore (svf-pore) family  1.F.1.2.1  
GO molecular function 
Calcium ion bindingdefinition[GO:0005509]  
1
  • UniProtKB
Calcium-dependent phospholipid bindingdefinition[GO:0005544]  
1
  • UniProtKB
Phospholipid bindingdefinition[GO:0005543]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
3
  • UniProtKB
  • IntAct
GO biological process 
Plasma membrane repairdefinition[GO:0001778] silver  
1
  • Ortholog Compara
Vesicle fusiondefinition[GO:0006906] silver  
1
  • Ortholog Compara
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Dysferlin
GenomeRNAi: 8291
PRO: PR:O75923