TRIO - Triple functional domain protein - human protein (Function)
 
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TRIO »  Triple functional domain protein
 
Gene name:  TRIO
Entry whose protein(s) existence is based on evidence at protein level
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Function

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Overview 
Promotes the exchange of GDP by GTP. Together with leukocyte antigen-related (LAR) protein, it could play a role in coordinating cell-matrix and cytoskeletal rearrangements necessary for cell migration and cell growth.  
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Enzyme bindingdefinition[GO:0019899] silver  
  • IEAOrtholog Compara
Guanyl-nucleotide exchange factor activitydefinition[GO:0005085]  
1
  • TASPINC
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
Protein serine/threonine kinase activitydefinition[GO:0004674]  
  • IEAUniProtKB KW
Rho guanyl-nucleotide exchange factor activitydefinition[GO:0005089] silver  
  • IEAInterPro 2 GO
GO biological process 
Positive regulation of GTPase activitydefinition[GO:0043547]  
1
  • TASGOC
Positive regulation of Rho GTPase activitydefinition[GO:0032321]  
  • IEAInterPro 2 GO
Protein phosphorylationdefinition[GO:0006468] silver  
  • IEAInterPro 2 GO
Transmembrane receptor protein tyrosine phosphatase signaling pathwaydefinition[GO:0007185]  
1
  • TASPINC
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.1: ATP + a protein ADP + a phosphoprotein.  
  • CuratedUniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathways:
DCC mediated attractive signaling  REACT_22351  
G alpha (12/13) signalling events  REACT_18407  
G alpha (q) signalling events  REACT_18283  
NRAGE signals death through JNK  REACT_13638  
Rho GTPase cycle  REACT_11051  
 

Keywords

Molecular function 
Guanine-nucleotide releasing factor  definition   [KW-0344]
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: TRIO_(gene)
GenomeRNAi: 7204
PRO: PR:O75962