TRIO - Triple functional domain protein - human protein (Function)
 
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TRIO »  Triple functional domain protein   [ EC 2.7.11.1 ]
 
Protein also known as:  PTPRF-interacting protein.
Gene name:  TRIO
Entry whose protein(s) existence is based on evidence at protein level
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1 66 5
GENE REF ISO

Function

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Overview 
Promotes the exchange of GDP by GTP. Together with leukocyte antigen-related (LAR) protein, it could play a role in coordinating cell-matrix and cytoskeletal rearrangements necessary for cell migration and cell growth.  
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Enzyme bindingdefinition[GO:0019899] silver  
  • IEAOrtholog Compara
Guanyl-nucleotide exchange factor activitydefinition[GO:0005085]  
1
  • TASPINC
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
Protein serine/threonine kinase activitydefinition[GO:0004674]  
  • IEAUniProtKB KW
Rho guanyl-nucleotide exchange factor activitydefinition[GO:0005089] silver  
  • IEAInterPro 2 GO
GO biological process 
Regulation of GTPase activitydefinition[GO:0043087]  
1
  • TASGOC
Transmembrane receptor protein tyrosine phosphatase signaling pathwaydefinition[GO:0007185]  
1
  • TASPINC
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.1: ATP + a protein ADP + a phosphoprotein.  
  • CuratedUniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathways:
Developmental Biology  REACT_111045  
Signal Transduction  REACT_111102  
 

Keywords

Molecular function 
Guanine-nucleotide releasing factor  definition   [KW-0344]
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: TRIO_(gene)
GenomeRNAi: 7204
PRO: PR:O75962