WFS1 - Wolframin - human protein (Function)
 
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Protein
Gene
References

 
WFS1 »  Wolframin
 
Gene name:  WFS1
Entry whose protein(s) existence is based on evidence at protein level
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1 108 1
GENE REF ISO

Function

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Overview 
Participates in the regulation of cellular Ca(2+) homeostasis, at least partly, by modulating the filling state of the endoplasmic reticulum Ca(2+) store.  
1
  • CuratedUniProtKB
GO molecular function 
Activating transcription factor bindingdefinition[GO:0033613]  
  • ISSOrtholog Curator
ATPase bindingdefinition[GO:0051117]  
1
  • IPIBHF-UCL
Calcium-dependent protein bindingdefinition[GO:0048306] silver  
  • IEAOrtholog Compara
Calmodulin bindingdefinition[GO:0005516] silver  
  • IEAOrtholog Compara
Transporter activitydefinition[GO:0005215]  
  • ISSOrtholog Curator
Ubiquitin protein ligase bindingdefinition[GO:0031625]  
  • ISSOrtholog Curator
GO biological process 
Calcium ion homeostasisdefinition[GO:0055074]  
1
  • IDABHF-UCL
Endoplasmic reticulum calcium ion homeostasisdefinition[GO:0032469]  
1
  • IDABHF-UCL
Endoplasmic reticulum unfolded protein responsedefinition[GO:0030968]  
  • ISSOrtholog Curator
ER overload responsedefinition[GO:0006983]  
2
  • TASBHF-UCL
ER-associated ubiquitin-dependent protein catabolic processdefinition[GO:0030433]  
  • ISSOrtholog Curator
Glucose homeostasisdefinition[GO:0042593]  
1
  • IMPBHF-UCL
Kidney developmentdefinition[GO:0001822]  
1
  • IMPBHF-UCL
Negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathwaydefinition[GO:1902236]  
  • ISSOrtholog Curator
Negative regulation of neuron apoptotic processdefinition[GO:0043524]  
2
  • IMPBHF-UCL
Negative regulation of programmed cell deathdefinition[GO:0043069]  
1
  • IMPBHF-UCL
Negative regulation of sequence-specific DNA binding transcription factor activitydefinition[GO:0043433]  
  • ISSOrtholog Curator
Negative regulation of type B pancreatic cell apoptotic processdefinition[GO:2000675]  
1
  • IMPBHF-UCL
Neurological system processdefinition[GO:0050877]  
1
  • IMPBHF-UCL
Olfactory behaviordefinition[GO:0042048] silver  
  • IEAOrtholog Compara
Polyubiquitinated misfolded protein transportdefinition[GO:0070845]  
  • ISSOrtholog Curator
Positive regulation of calcium ion transportdefinition[GO:0051928]  
1
  • IDABHF-UCL
Positive regulation of growthdefinition[GO:0045927]  
  • ISSOrtholog Curator
Positive regulation of protein metabolic processdefinition[GO:0051247]  
1
  • IDABHF-UCL
Positive regulation of protein ubiquitinationdefinition[GO:0031398]  
  • ISSOrtholog Curator
Positive regulation of proteolysisdefinition[GO:0045862]  
  • ISSOrtholog Curator
Protein maturation by protein foldingdefinition[GO:0022417]  
1
  • ICBHF-UCL
Protein stabilizationdefinition[GO:0050821]  
  • ISSOrtholog Curator
Renal water homeostasisdefinition[GO:0003091]  
1
  • IMPBHF-UCL
Response to endoplasmic reticulum stressdefinition[GO:0034976]  
1
  • IDABHF-UCL
Sensory perception of sounddefinition[GO:0007605]  
1
  • IMPBHF-UCL
Visual perceptiondefinition[GO:0007601]  
2
  • IMPBHF-UCL
Pathways 
According to KEGG, this protein belongs to the following pathway:
Protein processing in endoplasmic reticulum  hsa04141+7466  
According to Reactome, this protein belongs to the following pathway:
XBP1(S) activates chaperone genes  REACT_18273  
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: WFS1
GenomeRNAi: 7466
PRO: PR:O76024