CDKL5 - Cyclin-dependent kinase-like 5 - human protein (Function)
 
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CDKL5 »  Cyclin-dependent kinase-like 5   [ EC 2.7.11.22 ]
 
Protein also known as:  Serine/threonine-protein kinase 9.
Gene name:  CDKL5
Entry whose protein(s) existence is based on evidence at protein level
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1 148 2
GENE REF ISO

Function

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Overview 
Mediates phosphorylation of MECP2.  
3
  • UniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • HGNC
Cyclin-dependent protein serine/threonine kinase activitydefinition[GO:0004693]  
1
  • EC 2 GO
Kinase activitydefinition[GO:0016301]  
1
  • MGI
Protein kinase activitydefinition[GO:0004672]  
1
  • HGNC
Protein serine/threonine kinase activitydefinition[GO:0004674]  
1
  • PINC
Rac GTPase bindingdefinition[GO:0048365]  
1
  • Ortholog Curator
GO biological process 
Neuron migrationdefinition[GO:0001764]  
1
  • Ortholog Curator
Positive regulation of axon extensiondefinition[GO:0045773]  
1
  • Ortholog Curator
Positive regulation of dendrite morphogenesisdefinition[GO:0050775]  
1
  • Ortholog Curator
Positive regulation of Rac GTPase activitydefinition[GO:0032855]  
1
  • Ortholog Curator
Protein autophosphorylationdefinition[GO:0046777]  
1
  • HGNC
Protein phosphorylationdefinition[GO:0006468]  
1
  • PINC
Regulation of cell cycledefinition[GO:0051726]  
1
  • EC 2 GO
Regulation of dendrite developmentdefinition[GO:0050773]  
1
  • Ortholog Curator
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.22: ATP + a protein ADP + a phosphoprotein.  
1
  • UniProtKB
 
More information is available from:
 

Keywords

Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CDKL5
GenomeRNAi: 6792
PRO: PR:O76039