SLC22A5 - Solute carrier family 22 member 5 - human protein (Function)
 
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Protein
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SLC22A5 »  Solute carrier family 22 member 5
 
Protein also known as:  High-affinity sodium-dependent carnitine cotransporter.
Gene name:  SLC22A5
Entry whose protein(s) existence is based on evidence at protein level
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1 88 3
GENE REF ISO

Function

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Overview 
Sodium-ion dependent, high affinity carnitine transporter. Involved in the active cellular uptake of carnitine. Transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Also relative uptake activity ratio of carnitine to TEA is 11.3.  
1
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the major facilitator superfamily (mfs)  2.A.1.19.3  
GO molecular function 
Antibiotic transporter activitydefinition[GO:0042895] silver  
  • IEAOrtholog Compara
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Carnitine transmembrane transporter activitydefinition[GO:0015226]  
2
  • IMPBHF-UCL
Drug transmembrane transporter activitydefinition[GO:0015238]  
1
  • ICBHF-UCL
PDZ domain bindingdefinition[GO:0030165]  
1
  • IPIBHF-UCL
Protein bindingdefinition[GO:0005515]  
1
  • IPIBHF-UCL
Quaternary ammonium group transmembrane transporter activitydefinition[GO:0015651]  
1
  • IDABHF-UCL
Symporter activitydefinition[GO:0015293]  
  • IEAUniProtKB KW
GO biological process 
Carnitine transmembrane transportdefinition[GO:1902603]  
2
  • IMPGOC
Carnitine transportdefinition[GO:0015879]  
2
  • IMPBHF-UCL
Drug transmembrane transportdefinition[GO:0006855]  
1
  • ICGOC
Drug transportdefinition[GO:0015893]  
1
  • ICBHF-UCL
Positive regulation of intestinal epithelial structure maintenancedefinition[GO:0060731]  
1
  • IMPBHF-UCL
Quaternary ammonium group transportdefinition[GO:0015697]  
1
  • IDABHF-UCL
Quorum sensing involved in interaction with hostdefinition[GO:0052106]  
1
  • IMPBHF-UCL
Sodium ion transportdefinition[GO:0006814]  
  • IEAUniProtKB KW
Sodium-dependent organic cation transportdefinition[GO:0070715]  
2
  • IDABHF-UCL
Pathways 
According to Reactome, this protein belongs to the following pathway:
Transmembrane transport of small molecules  REACT_15518  
Note 
Inhibited by emetine, quinidine and verapamil. The IC(50) of emetine is 4.2 uM. Not inhibited by valproic acid.  
  • CuratedUniProtKB
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Sodium transport  definition   [KW-0739]
Symport  definition   [KW-0769]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: SLC22A5
GenomeRNAi: 6584
PRO: PR:O76082