BEST1 - Bestrophin-1 - human protein (Function)
 
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Protein
Gene
References

 
BEST1 »  Bestrophin-1
 
Protein also known as:  Vitelliform macular dystrophy protein 2.
Gene name:  BEST1
Family name: Bestrophin
Entry whose protein(s) existence is based on evidence at protein level
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1 116 3
GENE REF ISO

Function

 show evidences
Overview 
Forms calcium-sensitive chloride channels. Highly permeable to bicarbonate.  
3
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the anion channel-forming bestrophin (bestrophin) family  1.A.46.1.1  
GO molecular function 
Contributes to chloride channel activitydefinition[GO:0005254]  
1
  • IDAHGNC
GO biological process 
Chloride transmembrane transportdefinition[GO:1902476]  
1
  • IDAGOC
  • IEAUniProtKB KW
Chloride transportdefinition[GO:0006821]  
1
  • IDAMGI
Detection of light stimulus involved in visual perceptiondefinition[GO:0050908] silver  
  • IEAOrtholog Compara
Regulation of calcium ion transportdefinition[GO:0051924] silver  
  • IEAOrtholog Compara
Transepithelial chloride transportdefinition[GO:0030321]  
1
  • IDAHGNC
Visual perceptiondefinition[GO:0007601]  
1
  • TASPINC
Pathways 
According to Reactome, this protein belongs to the following pathway:
Stimuli-sensing channels  REACT_160189  
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Sensory transduction  definition   [KW-0716]
Transport  definition   [KW-0813]
Vision  definition   [KW-0844]
Molecular function 
Chloride channel  definition   [KW-0869]
Ion channel  definition   [KW-0407]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Bestrophin_1
GenomeRNAi: 7439
PRO: PR:O76090