BEST1 - Bestrophin-1 - human protein (Function)
 
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Protein
Gene
References

 
BEST1 »  Bestrophin-1
 
Protein also known as:  Vitelliform macular dystrophy protein 2.
Gene name:  BEST1
Family name: Bestrophin
Entry whose protein(s) existence is based on evidence at protein level
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1 118 3
GENE REF ISO

Function

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Overview 
Forms calcium-sensitive chloride channels. Highly permeable to bicarbonate.  
4
  • UniProtKB
According to TCDB this is a transporter from family:
the anion channel-forming bestrophin (bestrophin) family  1.A.46.1.1  
GO molecular function 
Contributes to chloride channel activitydefinition[GO:0005254]  
2
  • MGI
  • HGNC
GO biological process 
Chloride transmembrane transportdefinition[GO:1902476]  
2
  • GOC
  • UniProtKB KW
Chloride transportdefinition[GO:0006821]  
1
  • MGI
Detection of light stimulus involved in visual perceptiondefinition[GO:0050908] silver  
1
  • Ortholog Compara
Regulation of calcium ion transportdefinition[GO:0051924] silver  
1
  • Ortholog Compara
Transepithelial chloride transportdefinition[GO:0030321]  
1
  • HGNC
Visual perceptiondefinition[GO:0007601]  
1
  • PINC
Pathways 
According to Reactome, this protein belongs to the following pathways:
Orphan transporters  REACT_267716  
Stimuli-sensing channels  REACT_160189  
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Sensory transduction  definition   [KW-0716]
Transport  definition   [KW-0813]
Vision  definition   [KW-0844]
Molecular function 
Chloride channel  definition   [KW-0869]
Ion channel  definition   [KW-0407]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Bestrophin_1
GenomeRNAi: 7439
PRO: PR:O76090