MTA2 - Metastasis-associated protein MTA2 - human protein (Function)
 
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MTA2 »  Metastasis-associated protein MTA2
 
Protein also known as:  p53 target protein in deacetylase complex.
Gene name:  MTA2
Entry whose protein(s) existence is based on evidence at protein level
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1 76 2
GENE REF ISO

Function

 show evidences
Overview 
May be involved in the regulation of gene expression as repressor and activator. The repression might be related to covalent modification of histone proteins.  
  • CuratedUniProtKB
GO molecular function 
Histone deacetylase activitydefinition[GO:0004407] silver  
  • IEAOrtholog Compara
Contributes to nucleosomal DNA bindingdefinition[GO:0031492]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
2
  • IPIIntAct
Contributes to RNA polymerase II core promoter proximal region sequence-specific DNA bindingdefinition[GO:0000978]  
1
  • IDAUniProtKB
Contributes to RNA polymerase II distal enhancer sequence-specific DNA bindingdefinition[GO:0000980]  
1
  • IDAUniProtKB
RNA polymerase II repressing transcription factor bindingdefinition[GO:0001103]  
1
  • IPIBHF-UCL
RNA polymerase II transcription factor bindingdefinition[GO:0001085]  
1
  • IPIBHF-UCL
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700] silver  
  • IEAInterPro 2 GO
Transcription factor binding transcription factor activitydefinition[GO:0000989] silver  
  • IEAOrtholog Compara
Zinc ion bindingdefinition[GO:0008270] silver  
  • IEAInterPro 2 GO
GO biological process 
ATP-dependent chromatin remodelingdefinition[GO:0043044]  
1
  • IDAUniProtKB
Chromatin assembly or disassemblydefinition[GO:0006333]  
1
  • TASPINC
DNA methylationdefinition[GO:0006306] silver  
  • IEAOrtholog Compara
Histone deacetylationdefinition[GO:0016575] silver  
  • IEAOrtholog Compara
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122] silver  
  • IEAOrtholog Compara
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944] silver  
  • IEAOrtholog Compara
Pathways 
According to Reactome, this protein belongs to the following pathway:
RNA Polymerase I Transcription Initiation  REACT_953  
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: MTA2
GenomeRNAi: 9219
PRO: PR:O94776