MTA2 - Metastasis-associated protein MTA2 - human protein (Function)
 
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MTA2 »  Metastasis-associated protein MTA2
 
Protein also known as:  p53 target protein in deacetylase complex.
Gene name:  MTA2
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
May be involved in the regulation of gene expression as repressor and activator. The repression might be related to covalent modification of histone proteins.  
1
  • UniProtKB
GO molecular function 
Histone deacetylase activitydefinition[GO:0004407] silver  
1
  • Ortholog Compara
Contributes to nucleosomal DNA bindingdefinition[GO:0031492]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
2
  • IntAct
Contributes to RNA polymerase II core promoter proximal region sequence-specific DNA bindingdefinition[GO:0000978]  
1
  • UniProtKB
Contributes to RNA polymerase II distal enhancer sequence-specific DNA bindingdefinition[GO:0000980]  
1
  • UniProtKB
RNA polymerase II repressing transcription factor bindingdefinition[GO:0001103]  
1
  • BHF-UCL
RNA polymerase II transcription factor bindingdefinition[GO:0001085]  
1
  • BHF-UCL
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700] silver  
1
  • InterPro 2 GO
Transcription factor binding transcription factor activitydefinition[GO:0000989] silver  
1
  • Ortholog Compara
Zinc ion bindingdefinition[GO:0008270] silver  
1
  • InterPro 2 GO
GO biological process 
ATP-dependent chromatin remodelingdefinition[GO:0043044]  
1
  • UniProtKB
Chromatin assembly or disassemblydefinition[GO:0006333]  
1
  • PINC
DNA methylationdefinition[GO:0006306] silver  
1
  • Ortholog Compara
Histone deacetylationdefinition[GO:0016575] silver  
1
  • Ortholog Compara
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122] silver  
1
  • Ortholog Compara
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944] silver  
1
  • Ortholog Compara
Pathways 
According to Reactome, this protein belongs to the following pathways:
HDACs deacetylate histones  REACT_228222  
RNA Polymerase I Transcription Initiation  REACT_953  
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: MTA2
GenomeRNAi: 9219
PRO: PR:O94776