DPM2 - Dolichol phosphate-mannose biosynthesis regulatory protein - human protein (Function)
 
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Protein
Gene
References

 
DPM2 »  Dolichol phosphate-mannose biosynthesis regulatory protein
 
Protein also known as:  Dolichol-phosphate mannose synthase subunit 2 (DPM synthase subunit 2).
Gene name:  DPM2
Family name: DPM2
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 17 1
GENE REF ISO

Function

 show evidences
Overview 
Regulates the biosynthesis of dolichol phosphate-mannose. Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization and stable expression of DPM1. When associated with the GPI-GlcNAc transferase (GPI-GnT) complex enhances but is not essential for its activity.  
1
  • CuratedUniProtKB
GO molecular function 
Contributes to dolichyl-phosphate beta-D-mannosyltransferase activitydefinition[GO:0004582]  
1
  • IDAHGNC
Enzyme regulator activitydefinition[GO:0030234] silver  
  • IEAOrtholog Compara
Protein bindingdefinition[GO:0005515]  
1
  • IPIHGNC
GO biological process 
Dolichol metabolic processdefinition[GO:0019348] silver  
  • IEAOrtholog Compara
GPI anchor biosynthetic processdefinition[GO:0006506]  
1
  • IDAUniProtKB
Protein O-linked mannosylationdefinition[GO:0035269]  
1
  • TASHGNC
Regulation of protein stabilitydefinition[GO:0031647]  
1
  • IPIUniProtKB
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Glycosylphosphatidylinositol(GPI)-anchor biosynthesis  hsa00563+8818  
Metabolic pathways  hsa01100+8818  
N-Glycan biosynthesis  hsa00510+8818  
According to Reactome, this protein belongs to the following pathway:
Metabolism of proteins  REACT_17015  
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: DPM2
GenomeRNAi: 8818
PRO: PR:O94777