ALDH1A2 - Retinal dehydrogenase 2 - human protein (Function)
 
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ALDH1A2 »  Retinal dehydrogenase 2   [ EC 1.2.1.36 ]  (RalDH2)
 
Protein also known as:  Retinaldehyde-specific dehydrogenase type 2 (RALDH(II)).
Gene name:  ALDH1A2
Family name: Aldehyde dehydrogenase
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 37 4
GENE REF ISO

Function

 show evidences
Overview 
Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Does metabolize octanal and decanal but does not metabolize citral, benzaldehyde, acetaldehyde and propanal efficiently (By similarity).  
1
  • UniProtKB
GO molecular function 
3-chloroallyl aldehyde dehydrogenase activitydefinition[GO:0004028]  
2
  • RefGenome
  • Ortholog Curator
Aldehyde dehydrogenase (NAD) activitydefinition[GO:0004029]  
1
  • RefGenome
Retinal bindingdefinition[GO:0016918]  
1
  • Ortholog Curator
Retinal dehydrogenase activitydefinition[GO:0001758]  
2
  • Ortholog Curator
  • RefGenome
GO biological process 
9-cis-retinoic acid biosynthetic processdefinition[GO:0042904] silver  
1
  • Ortholog Compara
Anterior/posterior pattern specificationdefinition[GO:0009952] silver  
1
  • Ortholog Compara
Blood vessel developmentdefinition[GO:0001568] silver  
1
  • Ortholog Compara
Cardiac muscle tissue developmentdefinition[GO:0048738] silver  
1
  • Ortholog Compara
Cellular response to retinoic aciddefinition[GO:0071300] silver  
1
  • Ortholog Compara
Determination of bilateral symmetrydefinition[GO:0009855] silver  
1
  • Ortholog Compara
Embryonic camera-type eye developmentdefinition[GO:0031076] silver  
1
  • Ortholog Compara
Embryonic digestive tract developmentdefinition[GO:0048566] silver  
1
  • Ortholog Compara
Embryonic forelimb morphogenesisdefinition[GO:0035115] silver  
1
  • Ortholog Compara
Face developmentdefinition[GO:0060324] silver  
1
  • Ortholog Compara
Heart morphogenesisdefinition[GO:0003007] silver  
1
  • Ortholog Compara
Hindbrain developmentdefinition[GO:0030902] silver  
1
  • Ortholog Compara
Kidney developmentdefinition[GO:0001822] silver  
1
  • Ortholog Compara
Liver developmentdefinition[GO:0001889] silver  
1
  • Ortholog Compara
Lung developmentdefinition[GO:0030324] silver  
1
  • Ortholog Compara
Midgut developmentdefinition[GO:0007494] silver  
1
  • Ortholog Compara
Morphogenesis of embryonic epitheliumdefinition[GO:0016331] silver  
1
  • Ortholog Compara
Negative regulation of cell proliferationdefinition[GO:0008285]  
1
  • UniProtKB
Neural crest cell developmentdefinition[GO:0014032] silver  
1
  • Ortholog Compara
Neural tube developmentdefinition[GO:0021915]  
1
  • UniProtKB
Neuron differentiationdefinition[GO:0030182] silver  
1
  • Ortholog Compara
Oxidation-reduction processdefinition[GO:0055114]  
1
  • UniProtKB KW
Pancreas developmentdefinition[GO:0031016] silver  
1
  • Ortholog Compara
Pituitary gland developmentdefinition[GO:0021983] silver  
1
  • Ortholog Compara
Positive regulation of apoptotic processdefinition[GO:0043065] silver  
1
  • Ortholog Compara
Positive regulation of cell proliferationdefinition[GO:0008284] silver  
1
  • Ortholog Compara
Positive regulation of gene expressiondefinition[GO:0010628] silver  
1
  • Ortholog Compara
Proximal/distal pattern formationdefinition[GO:0009954] silver  
1
  • Ortholog Compara
Regulation of endothelial cell proliferationdefinition[GO:0001936] silver  
1
  • Ortholog Compara
Response to cytokinedefinition[GO:0034097]  
1
  • UniProtKB
Response to estradioldefinition[GO:0032355] silver  
1
  • Ortholog Compara
Response to vitamin Adefinition[GO:0033189] silver  
1
  • Ortholog Compara
Retinal metabolic processdefinition[GO:0042574] silver  
1
  • Ortholog Compara
Retinoic acid metabolic processdefinition[GO:0042573]  
1
  • Ortholog Curator
Retinoic acid receptor signaling pathwaydefinition[GO:0048384] silver  
1
  • Ortholog Compara
Retinol metabolic processdefinition[GO:0042572]  
1
  • UniPathway
Ureter maturationdefinition[GO:0035799] silver  
1
  • Ortholog Compara
Vitamin A metabolic processdefinition[GO:0006776]  
1
  • UniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 1.2.1.36: Retinal + NAD(+) + H(2)O retinoate + NADH.  
1
  • UniProtKB
Pathways 
This protein is involved in the following pathway
Cofactor metabolism; retinol metabolism  
1
  • UniProtKB
According to KEGG, this protein belongs to the following pathways:
Metabolic pathways  hsa01100+8854  
Retinol metabolism  hsa00830+8854  
According to Reactome, this protein belongs to the following pathway:
RA biosynthesis pathway  REACT_268561  
 
More information is available from:
 

Keywords

Molecular function 
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ALDH1A2
GenomeRNAi: 8854
PRO: PR:O94788