STK10 - Serine/threonine-protein kinase 10 - human protein (Function)
 
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STK10 »  Serine/threonine-protein kinase 10   [ EC 2.7.11.1 ]
 
Protein also known as:  Lymphocyte-oriented kinase.
Gene name:  STK10
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as MSN. Acts as a negative regulator of MAP3K1/MEKK1. May also act as a cell cycle regulator by acting as a polo kinase kinase: mediates phosphorylation of PLK1 in vitro; however such data require additional evidences in vivo.  
3
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Identical protein bindingdefinition[GO:0042802]  
1
  • IPIIntAct
Polo kinase kinase activitydefinition[GO:0042801]  
1
  • TASUniProtKB
Protein bindingdefinition[GO:0005515]  
2
  • IPIUniProtKB
Protein homodimerization activitydefinition[GO:0042803]  
1
  • IDAUniProtKB
Protein serine/threonine kinase activitydefinition[GO:0004674]  
2
  • IDAUniProtKB
GO biological process 
Cell cycledefinition[GO:0007049]  
  • IEAUniProtKB KW
Lymphocyte aggregationdefinition[GO:0071593] silver  
  • IEAOrtholog Compara
Protein autophosphorylationdefinition[GO:0046777]  
2
  • IDAUniProtKB
Protein phosphorylationdefinition[GO:0006468]  
1
  • TASPINC
Regulation of lymphocyte migrationdefinition[GO:2000401]  
1
  • IMPUniProtKB
Signal transduction by phosphorylationdefinition[GO:0023014]  
1
  • TASGOC
  • IBARefGenome
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.1: ATP + a protein ADP + a phosphoprotein.  
1
  • CuratedUniProtKB
It is regulated in the following manner
Inhibited by the pyrrole-indolinone inhibitor SU11274 (K00593): intercalates between the ATP-binding Lys-65 and alpha-C glutamate (Glu-81), resulting in a partial disordering of the lysine side chain. Also specifically inhibited by erlotinib. Slightly inhibited by gefitinib.  
2
  • CuratedUniProtKB
Note 
Inhibition by erlotinib, an orally administered EGFR tyrosine kinase inhibitor used for treatment, enhances STK10-dependent lymphocytic responses, possibly leading to the aggravation of skin inflammation observed upon treatment by erlotinib (PubMed21606217).  
1
  • CuratedUniProtKB
 

Keywords

Biological process 
Cell cycle  definition   [KW-0131]
Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: STK10
GenomeRNAi: 6793
PRO: PR:O94804
Chemistry
GuidetoPHARMACOLOGY: 2211