SLIT2 - Slit homolog 2 protein - human protein (Function)
 
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SLIT2 »  Slit homolog 2 protein  (Slit-2)
 
Cleaved into:  Slit homolog 2 protein C-product; Slit homolog 2 protein N-product.
Gene name:  SLIT2
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions. SLIT1 and SLIT2 seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb. In spinal chord development may play a role in guiding commissural axons once they reached the floor plate by modulating the response to netrin. In vitro, silences the attractive effect of NTN1 but not its growth-stimulatory effect and silencing requires the formation of a ROBO1-DCC complex. May be implicated in spinal chord midline post-crossing axon repulsion. In vitro, only commissural axons that crossed the midline responded to SLIT2. In the developing visual system appears to function as repellent for retinal ganglion axons by providing a repulsion that directs these axons along their appropriate paths prior to, and after passage through, the optic chiasm. In vitro, collapses and repels retinal ganglion cell growth cones. Seems to play a role in branching and arborization of CNS sensory axons, and in neuronal cell migration. In vitro, Slit homolog 2 protein N-product, but not Slit homolog 2 protein C-product, repels olfactory bulb (OB) but not dorsal root ganglia (DRG) axons, induces OB growth cones collapse and induces branching of DRG axons. Seems to be involved in regulating leukocyte migration.  
7
  • UniProtKB
GO molecular function 
Calcium ion bindingdefinition[GO:0005509]  
1
  • UniProtKB
Chemorepellent activitydefinition[GO:0045499] silver  
1
  • Ortholog Compara
GTPase inhibitor activitydefinition[GO:0005095]  
2
  • UniProtKB
Heparin bindingdefinition[GO:0008201]  
1
  • UniProtKB
Identical protein bindingdefinition[GO:0042802]  
1
  • IntAct
Laminin-1 bindingdefinition[GO:0043237]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
1
  • UniProtKB
Protein homodimerization activitydefinition[GO:0042803]  
1
  • UniProtKB
Proteoglycan bindingdefinition[GO:0043394]  
1
  • UniProtKB
Roundabout bindingdefinition[GO:0048495]  
3
  • UniProtKB
GO biological process 
Apoptotic process involved in luteolysisdefinition[GO:0061364]  
1
  • UniProtKB
Axon extension involved in axon guidancedefinition[GO:0048846]  
1
  • UniProtKB
Axon guidancedefinition[GO:0007411]  
1
  • UniProtKB
Branching morphogenesis of an epithelial tubedefinition[GO:0048754]  
2
  • UniProtKB
Cell migration involved in sprouting angiogenesisdefinition[GO:0002042]  
1
  • BHF-UCL
Cellular response to heparindefinition[GO:0071504]  
1
  • UniProtKB
Cellular response to hormone stimulusdefinition[GO:0032870]  
1
  • UniProtKB
Not  Chemorepulsion involved in embryonic olfactory bulb interneuron precursor migrationdefinition[GO:0021834]  
1
  • UniProtKB
Chemorepulsion involved in postnatal olfactory bulb interneuron migrationdefinition[GO:0021836]  
1
  • UniProtKB
Corticospinal neuron axon guidance through spinal corddefinition[GO:0021972]  
1
  • BHF-UCL
Dorsal/ventral axon guidancedefinition[GO:0033563] silver  
1
  • Ortholog Compara
In utero embryonic developmentdefinition[GO:0001701] silver  
1
  • Ortholog Compara
Induction of negative chemotaxisdefinition[GO:0050929]  
1
  • UniProtKB
Mammary duct terminal end bud growthdefinition[GO:0060763] silver  
1
  • Ortholog Compara
Metanephros developmentdefinition[GO:0001656] silver  
1
  • Ortholog Compara
Motor neuron axon guidancedefinition[GO:0008045]  
1
  • UniProtKB
Negative chemotaxisdefinition[GO:0050919]  
2
  • UniProtKB
Negative regulation of actin filament polymerizationdefinition[GO:0030837]  
1
  • UniProtKB
Negative regulation of axon extensiondefinition[GO:0030517] silver  
1
  • Ortholog Compara
Negative regulation of cell growthdefinition[GO:0030308]  
1
  • BHF-UCL
Negative regulation of cell migrationdefinition[GO:0030336]  
2
  • UniProtKB
Negative regulation of cell proliferationdefinition[GO:0008285] silver  
1
  • Ortholog Compara
Negative regulation of cellular response to growth factor stimulusdefinition[GO:0090288]  
1
  • BHF-UCL
Negative regulation of chemokine-mediated signaling pathwaydefinition[GO:0070100]  
1
  • BHF-UCL
Negative regulation of endothelial cell migrationdefinition[GO:0010596]  
1
  • UniProtKB
Negative regulation of gene expressiondefinition[GO:0010629] silver  
1
  • Ortholog Compara
Negative regulation of GTPase activitydefinition[GO:0034260]  
2
  • GOC
Negative regulation of lamellipodium assemblydefinition[GO:0010593]  
1
  • UniProtKB
Negative regulation of leukocyte chemotaxisdefinition[GO:0002689]  
1
  • UniProtKB
Negative regulation of monocyte chemotaxisdefinition[GO:0090027]  
1
  • Ortholog Curator
Negative regulation of mononuclear cell migrationdefinition[GO:0071676]  
1
  • BHF-UCL
Negative regulation of neutrophil chemotaxisdefinition[GO:0090024]  
1
  • UniProtKB
Negative regulation of protein phosphorylationdefinition[GO:0001933]  
1
  • UniProtKB
Negative regulation of retinal ganglion cell axon guidancedefinition[GO:0090260]  
1
  • UniProtKB
Negative regulation of small GTPase mediated signal transductiondefinition[GO:0051058]  
1
  • UniProtKB
Negative regulation of smooth muscle cell chemotaxisdefinition[GO:0071672]  
1
  • BHF-UCL
Negative regulation of smooth muscle cell migrationdefinition[GO:0014912]  
1
  • BHF-UCL
Negative regulation of vascular permeabilitydefinition[GO:0043116]  
1
  • UniProtKB
Positive regulation of apoptotic processdefinition[GO:0043065]  
1
  • UniProtKB
Positive regulation of axonogenesisdefinition[GO:0050772]  
1
  • UniProtKB
Response to cortisoldefinition[GO:0051414]  
1
  • UniProtKB
Retinal ganglion cell axon guidancedefinition[GO:0031290]  
2
  • UniProtKB
Roundabout signaling pathwaydefinition[GO:0035385]  
2
  • BHF-UCL
Single organismal cell-cell adhesiondefinition[GO:0016337] silver  
1
  • Ortholog Compara
Ureteric bud developmentdefinition[GO:0001657]  
1
  • UniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathway:
Axon guidance  hsa04360+9353  
According to Reactome, this protein belongs to the following pathways:
Activation of Rac  REACT_19226  
Inactivation of Cdc42 and Rac  REACT_19342  
Netrin-1 signaling  REACT_22237  
Regulation of Commissural axon pathfinding by Slit and Robo  REACT_19376  
Role of Abl in Robo-Slit signaling  REACT_19230  
Signaling by Robo receptor  REACT_19351  
 

Keywords

Biological process 
Chemotaxis  definition   [KW-0145]
Differentiation  definition   [KW-0221]
Neurogenesis  definition   [KW-0524]
Molecular function 
Developmental protein  definition   [KW-0217]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: SLIT2
GenomeRNAi: 9353
PRO: PR:O94813