SLIT2 - Slit homolog 2 protein - human protein (Function)
 
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SLIT2 »  Slit homolog 2 protein  (Slit-2)
 
Cleaved into:  Slit homolog 2 protein C-product; Slit homolog 2 protein N-product.
Gene name:  SLIT2
Entry whose protein(s) existence is based on evidence at protein level
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1 56 3
GENE REF ISO

Function

 show evidences
Overview 
Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions. SLIT1 and SLIT2 seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb. In spinal chord development may play a role in guiding commissural axons once they reached the floor plate by modulating the response to netrin. In vitro, silences the attractive effect of NTN1 but not its growth-stimulatory effect and silencing requires the formation of a ROBO1-DCC complex. May be implicated in spinal chord midline post-crossing axon repulsion. In vitro, only commissural axons that crossed the midline responded to SLIT2. In the developing visual system appears to function as repellent for retinal ganglion axons by providing a repulsion that directs these axons along their appropriate paths prior to, and after passage through, the optic chiasm. In vitro, collapses and repels retinal ganglion cell growth cones. Seems to play a role in branching and arborization of CNS sensory axons, and in neuronal cell migration. In vitro, Slit homolog 2 protein N-product, but not Slit homolog 2 protein C-product, repels olfactory bulb (OB) but not dorsal root ganglia (DRG) axons, induces OB growth cones collapse and induces branching of DRG axons. Seems to be involved in regulating leukocyte migration.  
6
  • CuratedUniProtKB
GO molecular function 
Calcium ion bindingdefinition[GO:0005509]  
1
  • NASUniProtKB
Chemorepellent activitydefinition[GO:0045499] silver  
  • IEAOrtholog Compara
GTPase inhibitor activitydefinition[GO:0005095]  
2
  • IDAUniProtKB
Heparin bindingdefinition[GO:0008201]  
1
  • IDAUniProtKB
Identical protein bindingdefinition[GO:0042802]  
1
  • IPIIntAct
Laminin-1 bindingdefinition[GO:0043237]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
Protein homodimerization activitydefinition[GO:0042803]  
1
  • IDAUniProtKB
Proteoglycan bindingdefinition[GO:0043394]  
1
  • IPIUniProtKB
Roundabout bindingdefinition[GO:0048495]  
3
  • IPIUniProtKB
GO biological process 
Apoptotic process involved in luteolysisdefinition[GO:0061364]  
1
  • IEPUniProtKB
Axon extension involved in axon guidancedefinition[GO:0048846]  
1
  • IDAUniProtKB
Axon guidancedefinition[GO:0007411]  
1
  • IDAUniProtKB
Branching morphogenesis of an epithelial tubedefinition[GO:0048754]  
2
  • IMPUniProtKB
Cell migration involved in sprouting angiogenesisdefinition[GO:0002042]  
1
  • IMPBHF-UCL
Cell-cell adhesiondefinition[GO:0016337] silver  
  • IEAOrtholog Compara
Cellular response to heparindefinition[GO:0071504]  
1
  • IDAUniProtKB
Cellular response to hormone stimulusdefinition[GO:0032870]  
1
  • IEPUniProtKB
Not  Chemorepulsion involved in embryonic olfactory bulb interneuron precursor migrationdefinition[GO:0021834]  
1
  • IDAUniProtKB
Chemorepulsion involved in postnatal olfactory bulb interneuron migrationdefinition[GO:0021836]  
1
  • IDAUniProtKB
Corticospinal neuron axon guidance through spinal corddefinition[GO:0021972]  
1
  • IMPBHF-UCL
Dorsal/ventral axon guidancedefinition[GO:0033563] silver  
  • IEAOrtholog Compara
In utero embryonic developmentdefinition[GO:0001701] silver  
  • IEAOrtholog Compara
Induction of negative chemotaxisdefinition[GO:0050929]  
1
  • IDAUniProtKB
Mammary duct terminal end bud growthdefinition[GO:0060763] silver  
  • IEAOrtholog Compara
Metanephros developmentdefinition[GO:0001656] silver  
  • IEAOrtholog Compara
Motor neuron axon guidancedefinition[GO:0008045]  
1
  • IDAUniProtKB
Negative chemotaxisdefinition[GO:0050919]  
2
  • IMPUniProtKB
Negative regulation of actin filament polymerizationdefinition[GO:0030837]  
1
  • IDAUniProtKB
Negative regulation of catalytic activitydefinition[GO:0043086]  
2
  • IDAGOC
Negative regulation of cell growthdefinition[GO:0030308]  
1
  • IMPBHF-UCL
Negative regulation of cell migrationdefinition[GO:0030336]  
2
  • IDAUniProtKB
Negative regulation of cell proliferationdefinition[GO:0008285] silver  
  • IEAOrtholog Compara
Negative regulation of cellular response to growth factor stimulusdefinition[GO:0090288]  
1
  • IDABHF-UCL
Negative regulation of chemokine-mediated signaling pathwaydefinition[GO:0070100]  
1
  • IMPBHF-UCL
Negative regulation of endothelial cell migrationdefinition[GO:0010596]  
1
  • IDAUniProtKB
Negative regulation of gene expressiondefinition[GO:0010629] silver  
  • IEAOrtholog Compara
Negative regulation of lamellipodium assemblydefinition[GO:0010593]  
1
  • IDAUniProtKB
Negative regulation of leukocyte chemotaxisdefinition[GO:0002689]  
1
  • IDAUniProtKB
Negative regulation of monocyte chemotaxisdefinition[GO:0090027]  
  • ISSOrtholog Curator
Negative regulation of mononuclear cell migrationdefinition[GO:0071676]  
1
  • IDABHF-UCL
Negative regulation of neutrophil chemotaxisdefinition[GO:0090024]  
1
  • IDAUniProtKB
Negative regulation of protein phosphorylationdefinition[GO:0001933]  
1
  • IDAUniProtKB
Negative regulation of retinal ganglion cell axon guidancedefinition[GO:0090260]  
1
  • IDAUniProtKB
Negative regulation of small GTPase mediated signal transductiondefinition[GO:0051058]  
1
  • IDAUniProtKB
Negative regulation of smooth muscle cell chemotaxisdefinition[GO:0071672]  
1
  • IDABHF-UCL
Negative regulation of smooth muscle cell migrationdefinition[GO:0014912]  
1
  • IDABHF-UCL
Negative regulation of vascular permeabilitydefinition[GO:0043116]  
1
  • IDAUniProtKB
Positive regulation of apoptotic processdefinition[GO:0043065]  
1
  • IMPUniProtKB
Positive regulation of axonogenesisdefinition[GO:0050772]  
1
  • TASUniProtKB
Regulation of catalytic activitydefinition[GO:0050790]  
2
  • IDAGOC
Response to cortisoldefinition[GO:0051414]  
1
  • IEPUniProtKB
Retinal ganglion cell axon guidancedefinition[GO:0031290]  
2
  • IDAUniProtKB
Roundabout signaling pathwaydefinition[GO:0035385]  
2
  • IMPBHF-UCL
Ureteric bud developmentdefinition[GO:0001657]  
1
  • IMPUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathway:
Axon guidance  hsa04360+9353  
According to Reactome, this protein belongs to the following pathways:
Developmental Biology  REACT_96538  
Developmental Biology  REACT_111045  
 

Keywords

Biological process 
Chemotaxis  definition   [KW-0145]
Differentiation  definition   [KW-0221]
Neurogenesis  definition   [KW-0524]
Molecular function 
Developmental protein  definition   [KW-0217]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: SLIT2
GenomeRNAi: 9353
PRO: PR:O94813