MICAL2 - Protein-methionine sulfoxide oxidase MICAL2 - human protein (Function)
 
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MICAL2 »  Protein-methionine sulfoxide oxidase MICAL2   [ EC 1.14.13.- ]
 
Protein also known as:  Molecule interacting with CasL protein 2 (MICAL-2).
Gene name:  MICAL2
Family name: Mical
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 26 6
GENE REF ISO

Function

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Overview 
Nuclear monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin and regulates the SRF signaling. Acts by modifying nuclear actin subunits through the addition of oxygen to form methionine-sulfoxide, leading to promote actin filament severing and prevent repolymerization. Acts as a key regulator of the SRF signaling pathway elicited by nerve growth factor and serum: mediates oxidation and subsequent depolymerization of nuclear actin, leading to increase MKL1/MRTF-A presence in the nucleus and promote SRF:MKL1/MRTF-A-dependent gene transcription. Does not activate SRF:MKL1/MRTF-A through RhoA.  
2
  • CuratedUniProtKB
GO molecular function 
Actin bindingdefinition[GO:0003779]  
1
  • IDAUniProtKB
  • ISSOrtholog Curator
FAD bindingdefinition[GO:0071949]  
  • ISSOrtholog Curator
NADPH:sulfur oxidoreductase activitydefinition[GO:0043914]  
1
  • IDAUniProtKB
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygendefinition[GO:0016709]  
  • ISSOrtholog Curator
Zinc ion bindingdefinition[GO:0008270] silver  
  • IEAInterPro 2 GO
GO biological process 
Actin filament depolymerizationdefinition[GO:0030042]  
1
  • IDAUniProtKB
  • ISSOrtholog Curator
Cytoskeleton organizationdefinition[GO:0007010]  
1
  • IDAUniProtKB
Heart developmentdefinition[GO:0007507]  
  • ISSOrtholog Curator
Heart loopingdefinition[GO:0001947]  
  • ISSOrtholog Curator
Oxidation-reduction processdefinition[GO:0055114]  
  • ISSOrtholog Curator
Positive regulation of transcription via serum response element bindingdefinition[GO:0010735]  
1
  • IMPUniProtKB
Sulfur oxidationdefinition[GO:0019417]  
1
  • IDAUniProtKB
  • ISSOrtholog Curator
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 1.14.13.-: [protein]-methionine + NADPH + O(2) [protein]-methionine-sulfoxide + NADP(+) + H(2)O.  
1
  • CuratedUniProtKB
It requires the following cofactor
FAD (By similarity).  
  • CuratedUniProtKB
It is regulated in the following manner
Specifically inhibited by CCG-1423, a small molecule inhibitor of SRF:MKL1/MRTF-A-dependent transcription.  
1
  • CuratedUniProtKB
 

Keywords

Molecular function 
Monooxygenase  definition   [KW-0503]
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: MICAL2
GenomeRNAi: 9645
PRO: PR:O94851