MICAL2 - Protein-methionine sulfoxide oxidase MICAL2 - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
MICAL2 »  Protein-methionine sulfoxide oxidase MICAL2   [ EC 1.14.13.- ]
 
Protein also known as:  Molecule interacting with CasL protein 2 (MICAL-2).
Gene name:  MICAL2
Family name: Mical
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 25 6
GENE REF ISO

Function

 show evidences
Overview 
Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin. Acts by modifying actin subunits through the addition of oxygen to form methionine-sulfoxide, leading to promote actin filament severing and prevent repolymerization (By similarity).  
  • CuratedUniProtKB
GO molecular function 
Actin bindingdefinition[GO:0003779]  
1
  • IDAUniProtKB
  • ISSOrtholog Curator
FAD bindingdefinition[GO:0071949]  
  • ISSOrtholog Curator
NADPH:sulfur oxidoreductase activitydefinition[GO:0043914]  
1
  • IDAUniProtKB
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygendefinition[GO:0016709]  
  • ISSOrtholog Curator
Zinc ion bindingdefinition[GO:0008270] silver  
  • IEAInterPro 2 GO
GO biological process 
Actin filament depolymerizationdefinition[GO:0030042]  
1
  • IDAUniProtKB
  • ISSOrtholog Curator
Cytoskeleton organizationdefinition[GO:0007010]  
1
  • IDAUniProtKB
Heart developmentdefinition[GO:0007507]  
  • ISSOrtholog Curator
Heart loopingdefinition[GO:0001947]  
  • ISSOrtholog Curator
Oxidation-reduction processdefinition[GO:0055114]  
  • ISSOrtholog Curator
Positive regulation of transcription via serum response element bindingdefinition[GO:0010735]  
1
  • IMPUniProtKB
Sulfur oxidationdefinition[GO:0019417]  
1
  • IDAUniProtKB
  • ISSOrtholog Curator
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 1.14.13.-: [protein]-methionine + NADPH + O(2) [protein]-methionine-sulfoxide + NADP(+) + H(2)O.  
  • CuratedUniProtKB
It requires the following cofactor
FAD (By similarity).  
  • CuratedUniProtKB
 

Keywords

Molecular function 
Monooxygenase  definition   [KW-0503]
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: MICAL2
GenomeRNAi: 9645
PRO: PR:O94851