MICAL2 - Protein-methionine sulfoxide oxidase MICAL2 - human protein (Function)
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MICAL2 »  Protein-methionine sulfoxide oxidase MICAL2   [ EC 1.14.13.- ]
Protein also known as:  Molecule interacting with CasL protein 2 (MICAL-2).
Gene name:  MICAL2
Family name: Mical
Entry whose protein(s) existence is based on evidence at protein level
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Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin. Acts by modifying actin subunits through the addition of oxygen to form methionine-sulfoxide, leading to promote actin filament severing and prevent repolymerization (By similarity).  
  • CuratedUniProtKB
GO molecular function 
Actin bindingdefinition[GO:0003779]  
  • ISSOrtholog Curator
FAD bindingdefinition[GO:0071949]  
  • ISSOrtholog Curator
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygendefinition[GO:0016709]  
  • ISSOrtholog Curator
Zinc ion bindingdefinition[GO:0008270] silver  
  • IEAInterPro 2 GO
GO biological process 
Actin filament depolymerizationdefinition[GO:0030042]  
  • ISSOrtholog Curator
Oxidation-reduction processdefinition[GO:0055114]  
  • ISSOrtholog Curator
Sulfur oxidationdefinition[GO:0019417]  
  • ISSOrtholog Curator
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 1.14.13.-: [protein]-methionine + NADPH + O(2) [protein]-methionine-sulfoxide + NADP(+) + H(2)O.  
  • CuratedUniProtKB
It requires the following cofactor
FAD (By similarity).  
  • CuratedUniProtKB


Molecular function 
Monooxygenase  definition   [KW-0503]
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]

Further external links

GeneWiki: MICAL2
GenomeRNAi: 9645
PRO: PR:O94851