PRPF6 - Pre-mRNA-processing factor 6 - human protein (Function)
 
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Protein
Gene
References

 
PRPF6 »  Pre-mRNA-processing factor 6
 
Protein also known as:  Androgen receptor N-terminal domain-transactivating protein 1 (ANT-1).
Gene name:  PRPF6
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 55 2
GENE REF ISO

Function

 show evidences
Overview 
Involved in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex, one of the building blocks of the spliceosome. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation.  
2
  • UniProtKB
GO molecular function 
Androgen receptor bindingdefinition[GO:0050681]  
1
  • MGI
Poly(A) RNA bindingdefinition[GO:0044822]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
3
  • IntAct
Ribonucleoprotein complex bindingdefinition[GO:0043021]  
1
  • BHF-UCL
RNA bindingdefinition[GO:0003723]  
1
  • MGI
Transcription coactivator activitydefinition[GO:0003713]  
1
  • MGI
GO biological process 
mRNA splicing, via spliceosomedefinition[GO:0000398]  
3
  • BHF-UCL
  • UniProtKB
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
1
  • MGI
RNA localizationdefinition[GO:0006403]  
1
  • MGI
RNA splicingdefinition[GO:0008380]  
1
  • UniProtKB
RNA splicing, via transesterification reactionsdefinition[GO:0000375]  
1
  • UniProtKB
Spliceosomal complex assemblydefinition[GO:0000245]  
1
  • UniProtKB
Spliceosomal tri-snRNP complex assemblydefinition[GO:0000244]  
2
  • BHF-UCL
Pathways 
According to KEGG, this protein belongs to the following pathway:
Spliceosome  hsa03040+24148  
According to Reactome, this protein belongs to the following pathways:
mRNA Splicing - Major Pathway  REACT_467  
mRNA Splicing - Minor Pathway  REACT_1753  
 

Keywords

Biological process 
mRNA processing  definition   [KW-0507]
mRNA splicing  definition   [KW-0508]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: PRPF6
GenomeRNAi: 24148
PRO: PR:O94906