LPHN1 - Latrophilin-1 - human protein (Function)
 
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Protein
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References

 
LPHN1 »  Latrophilin-1
 
Protein also known as:  Calcium-independent alpha-latrotoxin receptor 1 (CIRL-1).
Gene name:  LPHN1
Entry whose protein(s) existence is based on evidence at protein level
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1 27 2
GENE REF ISO

Function

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Overview 
Calcium-independent receptor of high affinity for alpha-latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor propably implicated in the regulation of exocytosis (By similarity).  
  • CuratedUniProtKB
GO molecular function 
Carbohydrate bindingdefinition[GO:0030246] silver  
  • IEAInterPro 2 GO
Cell adhesion molecule bindingdefinition[GO:0050839]  
  • ISSOrtholog Curator
G-protein coupled receptor activitydefinition[GO:0004930]  
  • IEAUniProtKB KW
Latrotoxin receptor activitydefinition[GO:0016524]  
  • ISSOrtholog Curator
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
GO biological process 
Calcium-mediated signaling using intracellular calcium sourcedefinition[GO:0035584]  
  • ISSOrtholog Curator
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
1
  • TASGDB
Heterophilic cell-cell adhesiondefinition[GO:0007157]  
  • ISSOrtholog Curator
Neuropeptide signaling pathwaydefinition[GO:0007218] silver  
  • IEAInterPro 2 GO
Positive regulation of synapse maturationdefinition[GO:0090129]  
  • ISSOrtholog Curator
Enzymatic activity 
 
More information is available from:
 

Keywords

Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: LPHN1
GenomeRNAi: 22859
PRO: PR:O94910