ABCA8 - ATP-binding cassette sub-family A member 8 - human protein (Function)
 
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Protein
Gene
References

 
ABCA8 »  ATP-binding cassette sub-family A member 8
 
Gene name:  ABCA8
Family name: ABC transporter » ABCA
Entry whose protein(s) existence is based on evidence at protein level
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1 32 3
GENE REF ISO

Function

 show evidences
Overview 
ATP-dependent lipophilic drug transporter.  
1
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the atp-binding cassette (abc) superfamily  3.A.1.211.6  
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
ATPase activity, coupled to transmembrane movement of substancesdefinition[GO:0042626]  
1
  • IDAMGI
GO biological process 
ATP catabolic processdefinition[GO:0006200]  
1
  • IDAGOC
Metabolic processdefinition[GO:0008152]  
1
  • IDAGOC
Transportdefinition[GO:0006810]  
1
  • IDAMGI
Pathways 
According to KEGG, this protein belongs to the following pathway:
ABC transporters  hsa02010+10351  
According to Reactome, this protein belongs to the following pathway:
Transmembrane transport of small molecules  REACT_15518  
 

Biophysicochemical properties

Kinetic parameters
KM 30.4 uM for estradiol-beta-glucuronide
KM 0.1 uM for LTC4
KM 0.5 uM for estrone sulfate
KM 5.0 uM for PAH
KM 0.4 uM for ochratoxin A
KM 10.3 uM for taurochlorate

Keywords

Biological process 
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: O94911
Other
GeneWiki: ABCA8
GenomeRNAi: 10351
PRO: PR:O94911