CDK14 - Cyclin-dependent kinase 14 - human protein (Function)
 
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CDK14 »  Cyclin-dependent kinase 14   [ EC 2.7.11.22 ]
 
Protein also known as:  Serine/threonine-protein kinase PFTAIRE-1.
Gene name:  CDK14
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by mediating the phosphorylation of LRP6 at 'Ser-1490', leading to the activation of the Wnt signaling pathway. Acts as a regulator of cell cycle progression and cell proliferation via its interaction with CCDN3. Phosphorylates RB1 in vitro, however the relevance of such result remains to be confirmed in vivo. May also play a role in meiosis, neuron differentiation and may indirectly act as a negative regulator of insulin-responsive glucose transport.  
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  • UniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
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  • UniProtKB KW
Cyclin bindingdefinition[GO:0030332]  
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  • UniProtKB
Cyclin-dependent protein serine/threonine kinase activitydefinition[GO:0004693]  
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  • UniProtKB
Protein bindingdefinition[GO:0005515]  
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  • IntAct
GO biological process 
Cell divisiondefinition[GO:0051301]  
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  • UniProtKB KW
G2/M transition of mitotic cell cycledefinition[GO:0000086]  
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  • UniProtKB
Protein phosphorylationdefinition[GO:0006468] silver  
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  • InterPro 2 GO
Regulation of canonical Wnt signaling pathwaydefinition[GO:0060828]  
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  • UniProtKB
Regulation of cell cycledefinition[GO:0051726]  
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  • GOC
  • EC 2 GO
Wnt signaling pathwaydefinition[GO:0016055]  
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  • UniProtKB KW
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.22: ATP + a protein ADP + a phosphoprotein.  
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  • UniProtKB
It is regulated in the following manner
Serine/threonine-protein kinase activity is promoted by associated cyclins CCDN3 and CCNY and repressed by CDKN1A.  
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  • UniProtKB
 

Keywords

Biological process 
Cell cycle  definition   [KW-0131]
Cell division  definition   [KW-0132]
Wnt signaling pathway  definition   [KW-0879]
Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: PFTK1
GenomeRNAi: 5218
PRO: PR:O94921
Chemistry
GuidetoPHARMACOLOGY: 1967