GLCE - D-glucuronyl C5-epimerase - human protein (Function)
 
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Protein
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References

 
GLCE »  D-glucuronyl C5-epimerase   [ EC 5.1.3.17 ]
 
Protein also known as:  Heparin/heparan sulfate:glucuronic acid C5-epimerase.
Gene name:  GLCE
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Converts D-glucuronic acid residues adjacent to N-sulfate sugar residues to L-iduronic acid residues, both in maturing heparan sulfate (HS) and heparin chains. This is important for further modifications that determine the specificity of interactions between these glycosaminoglycans and proteins.  
1
  • CuratedUniProtKB
GO molecular function 
Heparosan-N-sulfate-glucuronate 5-epimerase activitydefinition[GO:0047464]  
1
  • IMPUniProtKB
Racemase and epimerase activity, acting on carbohydrates and derivativesdefinition[GO:0016857]  
  • ISSOrtholog Curator
UDP-glucuronate 5'-epimerase activitydefinition[GO:0050379]  
1
  • IDAHGNC
GO biological process 
Heparan sulfate proteoglycan biosynthetic processdefinition[GO:0015012]  
1
  • IDAUniProtKB
  • IEAUniPathway
  • ISSOrtholog Curator
Heparin biosynthetic processdefinition[GO:0030210]  
  • ISSOrtholog Curator
  • IEAUniPathway
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 5.1.3.17: Heparosan-N-sulfate D-glucuronate heparosan-N-sulfate L-iduronate.  
2
  • CuratedUniProtKB
Pathways 
This protein is involved in the following pathways
According to KEGG, this protein belongs to the following pathways:
Glycosaminoglycan biosynthesis - heparan sulfate  hsa00534+26035  
Metabolic pathways  hsa01100+26035  
According to Reactome, this protein belongs to the following pathway:
HS-GAG biosynthesis  REACT_121248  
 

Keywords

Molecular function 
Isomerase  definition   [KW-0413]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: GLCE
GenomeRNAi: 26035
PRO: PR:O94923