TRIM37 - E3 ubiquitin-protein ligase TRIM37 - human protein (Function)
 
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Protein
Gene
References

 
TRIM37 »  E3 ubiquitin-protein ligase TRIM37   [ EC 6.3.2.- ]
 
Protein also known as:  Tripartite motif-containing protein 37.
Gene name:  TRIM37
Family name: TRIM/RBCC
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 37 2
GENE REF ISO

Function

 show evidences
Overview 
E3 ubiquitin-protein ligase required to prevent centriole reduplication. Probably acts by ubiquitinating positive regulators of centriole reduplication.  
2
  • CuratedUniProtKB
GO molecular function 
Ligase activitydefinition[GO:0016874]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
3
  • IPIIntAct
  • IPIUniProtKB
Protein homodimerization activitydefinition[GO:0042803]  
1
  • IDAUniProtKB
Tumor necrosis factor receptor bindingdefinition[GO:0005164]  
1
  • IPIUniProtKB
Ubiquitin protein ligase bindingdefinition[GO:0031625]  
1
  • IPIUniProtKB
Ubiquitin-protein transferase activitydefinition[GO:0004842]  
1
  • IDAUniProtKB
Zinc ion bindingdefinition[GO:0008270] silver  
  • IEAInterPro 2 GO
GO biological process 
Aggresome assemblydefinition[GO:0070842]  
1
  • IDAUniProtKB
Negative regulation of centriole replicationdefinition[GO:0046600]  
1
  • IMPUniProtKB
Negative regulation of NF-kappaB transcription factor activitydefinition[GO:0032088]  
1
  • IDAUniProtKB
Positive regulation of NF-kappaB transcription factor activitydefinition[GO:0051092]  
1
  • IDAUniProtKB
Positive regulation of sequence-specific DNA binding transcription factor activitydefinition[GO:0051091]  
1
  • IDAUniProtKB
Protein autoubiquitinationdefinition[GO:0051865]  
1
  • IDAUniProtKB
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathway:
Ubiquitin mediated proteolysis  hsa04120+4591  
According to Reactome, this protein belongs to the following pathway:
Antigen processing: Ubiquitination & Proteasome degradation  REACT_75842  
 

Keywords

Biological process 
Ubl conjugation pathway  definition   [KW-0833]
Molecular function 
Ligase  definition   [KW-0436]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: TRIM37
GenomeRNAi: 4591
PRO: PR:O94972