KCNK2 - Potassium channel subfamily K member 2 - human protein (Function)
 
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Protein
Gene
References

 
KCNK2 »  Potassium channel subfamily K member 2
 
Protein also known as:  Outward rectifying potassium channel protein TREK-1.
Gene name:  KCNK2
Entry whose protein(s) existence is based on evidence at protein level
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1 52 4
GENE REF ISO

Function

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Overview 
Reversibly converts between a voltage-insensitive potassium leak channel and a voltage-dependent outward rectifying potassium channel in a phosphorylation-dependent manner.  
3
  • CuratedUniProtKB
GO molecular function 
Outward rectifier potassium channel activitydefinition[GO:0015271]  
  • ISSOrtholog Curator
Isoform  Iso 4   Potassium channel inhibitor activitydefinition[GO:0019870]  
  • ISSOrtholog Curator
Potassium ion leak channel activitydefinition[GO:0022841]  
  • ISSOrtholog Curator
GO biological process 
G-protein coupled receptor signaling pathwaydefinition[GO:0007186] silver  
  • IEAOrtholog Compara
Potassium ion transmembrane transportdefinition[GO:0071805]  
  • ISSOrtholog Curator
Regulation of ion transmembrane transportdefinition[GO:0034765]  
  • IEAUniProtKB KW
Pathways 
According to KEGG, this protein belongs to the following pathway:
Gastric acid secretion  hsa04971+3776  
According to Reactome, this protein belongs to the following pathway:
TWIK related potassium channel (TREK)  REACT_75819  
Note 
Activated by volatile general anesthetics such as chloroform, halothane and isoflurane.  
  • CuratedUniProtKB
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Potassium transport  definition   [KW-0633]
Transport  definition   [KW-0813]
Molecular function 
Ion channel  definition   [KW-0407]
Potassium channel  definition   [KW-0631]
Voltage-gated channel  definition   [KW-0851]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: KCNK2
GenomeRNAi: 3776
PRO: PR:O95069
Chemistry
GuidetoPHARMACOLOGY: 514