KCNK2 - Potassium channel subfamily K member 2 - human protein (Function)
 
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Protein
Gene
References

 
KCNK2 »  Potassium channel subfamily K member 2
 
Protein also known as:  Outward rectifying potassium channel protein TREK-1.
Gene name:  KCNK2
Entry whose protein(s) existence is based on evidence at protein level
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1 69 4
GENE REF ISO

Function

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Overview 
Ion channel that contributes to passive transmembrane potassium transport (PubMed23169818). Reversibly converts between a voltage-insensitive potassium leak channel and a voltage-dependent outward rectifying potassium channel in a phosphorylation-dependent manner (PubMed11319556). In astrocytes, forms mostly heterodimeric potassium channels with KCNK1, with only a minor proportion of functional channels containing homodimeric KCNK2. In astrocytes, the heterodimer formed by KCNK1 and KCNK2 is required for rapid glutamate release in response to activation of G-protein coupled receptors, such as F2R and CNR1 (By similarity).  
5
  • UniProtKB
Isoform  Iso 4   Does not display channel activity but reduces the channel activity of isoform 1 and isoform 2 and reduces cell surface expression of isoform 2.  
1
  • UniProtKB
GO molecular function 
Outward rectifier potassium channel activitydefinition[GO:0015271]  
2
  • RefGenome
  • Ortholog Curator
Potassium channel inhibitor activitydefinition[GO:0019870]  
2
  • Ortholog Compara
  • Ortholog Curator
Potassium ion leak channel activitydefinition[GO:0022841]  
2
  • Ortholog Curator
  • RefGenome
GO biological process 
Cardiac ventricle developmentdefinition[GO:0003231] silver  
1
  • Ortholog Compara
Cellular response to hypoxiadefinition[GO:0071456] silver  
1
  • Ortholog Compara
Cochlea developmentdefinition[GO:0090102] silver  
1
  • Ortholog Compara
G-protein coupled receptor signaling pathwaydefinition[GO:0007186] silver  
1
  • Ortholog Compara
Memorydefinition[GO:0007613] silver  
1
  • Ortholog Compara
Negative regulation of cardiac muscle cell proliferationdefinition[GO:0060044] silver  
1
  • Ortholog Compara
Negative regulation of DNA biosynthetic processdefinition[GO:2000279] silver  
1
  • Ortholog Compara
Positive regulation of cell deathdefinition[GO:0010942] silver  
1
  • Ortholog Compara
Positive regulation of cellular response to hypoxiadefinition[GO:1900039] silver  
1
  • Ortholog Compara
Potassium ion transmembrane transportdefinition[GO:0071805]  
2
  • RefGenome
  • Ortholog Curator
Response to axon injurydefinition[GO:0048678] silver  
1
  • Ortholog Compara
Response to mechanical stimulusdefinition[GO:0009612] silver  
1
  • Ortholog Compara
Stabilization of membrane potentialdefinition[GO:0030322]  
1
  • RefGenome
Pathways 
According to KEGG, this protein belongs to the following pathway:
Gastric acid secretion  hsa04971+3776  
According to Reactome, this protein belongs to the following pathway:
TWIK related potassium channel (TREK)  R-HSA-1299503  
Note 
Activated by volatile general anesthetics such as chloroform, halothane and isoflurane.  
1
  • UniProtKB
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Potassium transport  definition   [KW-0633]
Transport  definition   [KW-0813]
Molecular function 
Ion channel  definition   [KW-0407]
Potassium channel  definition   [KW-0631]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: KCNK2
GenomeRNAi: 3776
PRO: PR:O95069
Chemistry
GuidetoPHARMACOLOGY: 514