S1PR2 - Sphingosine 1-phosphate receptor 2 - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
S1PR2 »  Sphingosine 1-phosphate receptor 2  (S1P2)
 
Protein also known as:  Endothelial differentiation G-protein coupled receptor 5.
Gene name:  S1PR2
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 43 1
GENE REF ISO

Function

 show evidences
Overview 
Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis.  
  • CuratedUniProtKB
GO molecular function 
G-protein coupled receptor activitydefinition[GO:0004930]  
1
  • TASPINC
G-protein coupled receptor bindingdefinition[GO:0001664]  
1
  • IPIUniProtKB
Integrin bindingdefinition[GO:0005178]  
1
  • IPIUniProtKB
Lipid bindingdefinition[GO:0008289]  
1
  • TASPINC
Sphingosine-1-phosphate receptor activitydefinition[GO:0038036] silver  
  • IEAInterPro 2 GO
GO biological process 
Activation of MAPK activitydefinition[GO:0000187]  
1
  • TASPINC
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
1
  • TASPINC
Negative regulation of excitatory postsynaptic membrane potentialdefinition[GO:0090394] silver  
  • IEAOrtholog Compara
Positive regulation of cell proliferationdefinition[GO:0008284]  
1
  • TASPINC
Positive regulation of establishment of endothelial barrierdefinition[GO:1903142]  
1
  • IMPUniProtKB
Sphingosine-1-phosphate signaling pathwaydefinition[GO:0003376]  
  • IEAInterPro 2 GO
Pathways 
According to KEGG, this protein belongs to the following pathway:
Neuroactive ligand-receptor interaction  hsa04080+9294  
According to Reactome, this protein belongs to the following pathways:
G alpha (i) signalling events  REACT_19231  
Lysosphingolipid and LPA receptors  REACT_18365  
 

Keywords

Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: S1PR2
GenomeRNAi: 9294
PRO: PR:O95136
Chemistry
GuidetoPHARMACOLOGY: 276