GABARAP - Gamma-aminobutyric acid receptor-associated protein - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
GABARAP »  Gamma-aminobutyric acid receptor-associated protein
 
Protein also known as:  GABA(A) receptor-associated protein.
Gene name:  GABARAP
Family name: ATG8
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 49 1
GENE REF ISO

Function

 show evidences
Overview 
Ubiquitin-like modifier that plays a role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton. Involved in apoptosis. Involved in autophagy. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation.  
1
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family  1.A.9.5.2  
GO molecular function 
Beta-tubulin bindingdefinition[GO:0048487]  
1
  • IDAUniProtKB
GABA receptor bindingdefinition[GO:0050811]  
1
  • IPIUniProtKB
Microtubule bindingdefinition[GO:0008017] silver  
  • IEAOrtholog Compara
Protein bindingdefinition[GO:0005515]  
16
  • IPIUniProtKB
  • IPIIntAct
GO biological process 
Autophagydefinition[GO:0006914]  
  • IEAUniProtKB KW
Extrinsic apoptotic signaling pathway via death domain receptorsdefinition[GO:0008625]  
1
  • IDAUniProtKB
Microtubule cytoskeleton organizationdefinition[GO:0000226] silver  
  • IEAOrtholog Compara
Protein targetingdefinition[GO:0006605]  
1
  • TASPINC
Synaptic transmissiondefinition[GO:0007268]  
1
  • TASPINC
Pathways 
According to KEGG, this protein belongs to the following pathways:
GABAergic synapse  hsa04727+11337  
Regulation of autophagy  hsa04140+11337  
 

Keywords

Biological process 
Apoptosis  definition   [KW-0053]
Autophagy  definition   [KW-0072]
Protein transport  definition   [KW-0653]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: GABARAP
GenomeRNAi: 11337
PRO: PR:O95166