CACNA1H - Voltage-dependent T-type calcium channel subunit alpha-1H - human protein (Function)
 
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CACNA1H »  Voltage-dependent T-type calcium channel subunit alpha-1H
 
Protein also known as:  Low-voltage-activated calcium channel alpha1 3.2 subunit.
Gene name:  CACNA1H
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1H gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite negative potentials, and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes.  
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the voltage-gated ion channel (vic) superfamily  1.A.1.11.5  
GO molecular function 
Low voltage-gated calcium channel activitydefinition[GO:0008332]  
1
  • IDABHF-UCL
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Scaffold protein bindingdefinition[GO:0097110]  
1
  • IPIBHF-UCL
GO biological process 
Aldosterone biosynthetic processdefinition[GO:0032342]  
1
  • IMPUniProtKB
Calcium ion importdefinition[GO:0070509]  
1
  • IDABHF-UCL
Cellular response to hormone stimulusdefinition[GO:0032870]  
1
  • IEPUniProtKB
Cellular response to potassium iondefinition[GO:0035865]  
1
  • IEPUniProtKB
Cortisol biosynthetic processdefinition[GO:0034651]  
1
  • IMPUniProtKB
Muscle contractiondefinition[GO:0006936]  
1
  • TASPINC
Muscle organ developmentdefinition[GO:0007517]  
1
  • NASPINC
Myoblast fusiondefinition[GO:0007520]  
1
  • TASPINC
Positive regulation of acrosome reactiondefinition[GO:2000344]  
1
  • IMPUniProtKB
Regulation of heart contractiondefinition[GO:0008016]  
1
  • TASPINC
Regulation of membrane potentialdefinition[GO:0042391]  
1
  • IDABHF-UCL
Transportdefinition[GO:0006810]  
1
  • TASPINC
Pathways 
According to KEGG, this protein belongs to the following pathways:
Calcium signaling pathway  hsa04020+8912  
MAPK signaling pathway  hsa04010+8912  
According to Reactome, this protein belongs to the following pathway:
Developmental Biology  REACT_111045  
 

Keywords

Biological process 
Calcium transport  definition   [KW-0109]
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Molecular function 
Calcium channel  definition   [KW-0107]
Ion channel  definition   [KW-0407]
Voltage-gated channel  definition   [KW-0851]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: CACNA1H
GenomeRNAi: 8912
PRO: PR:O95180
Chemistry
GuidetoPHARMACOLOGY: 536