RTN3 - Reticulon-3 - human protein (Function)
 
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Protein
Gene
References

 
RTN3 »  Reticulon-3
 
Protein also known as:  Neuroendocrine-specific protein-like II (NSPLII).
Gene name:  RTN3
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
May be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and amyloid precursor protein processing. May induce caspase-8 cascade and apoptosis. May favor BCL2 translocation to the mitochondria upon endoplasmic reticulum stress. In case of enteroviruses infection, RTN3 may be involved in the viral replication or pathogenesis.  
4
  • CuratedUniProtKB
GO biological process 
Apoptotic processdefinition[GO:0006915]  
  • IEAUniProtKB KW
Endoplasmic reticulum tubular network organizationdefinition[GO:0071786]  
1
  • IMPUniProtKB
Response to stressdefinition[GO:0006950]  
  • IEAUniProtKB KW
Vesicle-mediated transportdefinition[GO:0016192]  
  • IEAUniProtKB KW
Viral processdefinition[GO:0016032]  
  • IEAUniProtKB KW
 

Keywords

Biological process 
Apoptosis  definition   [KW-0053]
ER-Golgi transport  definition   [KW-0931]
Host-virus interaction  definition   [KW-0945]
Stress response  definition   [KW-0346]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: RTN3
GenomeRNAi: 10313
PRO: PR:O95197