ABCC6 - Multidrug resistance-associated protein 6 - human protein (Function)
 
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Protein
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References

 
ABCC6 »  Multidrug resistance-associated protein 6
 
Protein also known as:  Anthracycline resistance-associated protein.
Gene name:  ABCC6
Entry whose protein(s) existence is based on evidence at protein level
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1 92 2
GENE REF ISO

Function

 show evidences
Overview 
May participate directly in the active transport of drugs into subcellular organelles or influence drug distribution indirectly. Transports glutathione conjugates as leukotriene-c4 (LTC4) and N-ethylmaleimide S-glutathione (NEM-GS).  
1
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the atp-binding cassette (abc) superfamily  3.A.1.208.10  
GO molecular function 
ATP bindingdefinition[GO:0005524] silver  
  • IEAOrtholog Compara
ATPase activity, coupled to transmembrane movement of substancesdefinition[GO:0042626] silver  
  • IEAInterPro 2 GO
Transporter activitydefinition[GO:0005215]  
1
  • TASPINC
GO biological process 
Response to drugdefinition[GO:0042493]  
1
  • TASPINC
Transportdefinition[GO:0006810]  
1
  • TASPINC
Visual perceptiondefinition[GO:0007601]  
  • IEAUniProtKB KW
Pathways 
According to KEGG, this protein belongs to the following pathway:
ABC transporters  hsa02010+368  
According to Reactome, this protein belongs to the following pathway:
Transmembrane transport of small molecules  REACT_15518  
 

Keywords

Biological process 
Sensory transduction  definition   [KW-0716]
Transport  definition   [KW-0813]
Vision  definition   [KW-0844]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ABCC6
GenomeRNAi: 368
PRO: PR:O95255