KCNH1 - Potassium voltage-gated channel subfamily H member 1 - human protein (Function)
 
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KCNH1 »  Potassium voltage-gated channel subfamily H member 1
 
Protein also known as:  Voltage-gated potassium channel subunit Kv10.1.
Gene name:  KCNH1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 79 2
GENE REF ISO

Function

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Overview 
Pore-forming (alpha) subunit of a voltage-gated delayed rectifier potassium channel (PubMed22732247). Channel properties may be modulated by subunit assembly, but not by cyclic nucleotides (By similarity). Mediates IK(NI) current in myoblasts (PubMed9738473). Involved in the regulation of cell proliferation and differentiation, in particular adipogenic and osteogenic differentiation in bone marrow-derived mesenchymal stem cells (MSCs) (PubMed23881642).  
5
  • UniProtKB
GO molecular function 
Calmodulin bindingdefinition[GO:0005516]  
1
  • UniProtKB KW
Not  Cyclic nucleotide bindingdefinition[GO:0030551]  
1
  • Ortholog Curator
Delayed rectifier potassium channel activitydefinition[GO:0005251]  
1
  • UniProtKB
Phosphorelay sensor kinase activitydefinition[GO:0000155] silver  
1
  • InterPro 2 GO
Protein bindingdefinition[GO:0005515]  
4
  • IntAct
GO biological process 
Myoblast fusiondefinition[GO:0007520]  
1
  • PINC
Phosphorelay signal transduction systemdefinition[GO:0000160] silver  
1
  • InterPro 2 GO
Potassium ion transmembrane transportdefinition[GO:0071805]  
2
  • UniProtKB
  • RefGenome
Potassium ion transportdefinition[GO:0006813]  
1
  • PINC
Regulation of cell proliferationdefinition[GO:0042127]  
1
  • UniProtKB
Regulation of ion transmembrane transportdefinition[GO:0034765]  
1
  • UniProtKB KW
Regulation of membrane potentialdefinition[GO:0042391]  
1
  • RefGenome
Signal transduction by protein phosphorylationdefinition[GO:0023014]  
1
  • InterPro 2 GO
Pathways 
According to Reactome, this protein belongs to the following pathway:
Voltage gated Potassium channels  REACT_75770  
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Potassium transport  definition   [KW-0633]
Transport  definition   [KW-0813]
Molecular function 
Ion channel  definition   [KW-0407]
Potassium channel  definition   [KW-0631]
Voltage-gated channel  definition   [KW-0851]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: KCNH1
GenomeRNAi: 3756
PRO: PR:O95259
Chemistry
GuidetoPHARMACOLOGY: 570