KCNH1 - Potassium voltage-gated channel subfamily H member 1 - human protein (Function)
 
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KCNH1 »  Potassium voltage-gated channel subfamily H member 1
 
Protein also known as:  Voltage-gated potassium channel subunit Kv10.1.
Gene name:  KCNH1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 89 2
GENE REF ISO

Function

 show evidences
Overview 
Pore-forming (alpha) subunit of a voltage-gated delayed rectifier potassium channel (PubMed22732247). Channel properties may be modulated by subunit assembly, but not by cyclic nucleotides (By similarity). Mediates IK(NI) current in myoblasts (PubMed9738473). Involved in the regulation of cell proliferation and differentiation, in particular adipogenic and osteogenic differentiation in bone marrow-derived mesenchymal stem cells (MSCs) (PubMed23881642).  
5
  • UniProtKB
GO molecular function 
14-3-3 protein bindingdefinition[GO:0071889] silver  
1
  • Ortholog Compara
Calmodulin bindingdefinition[GO:0005516]  
1
  • UniProtKB KW
Not  Cyclic nucleotide bindingdefinition[GO:0030551]  
1
  • Ortholog Curator
Delayed rectifier potassium channel activitydefinition[GO:0005251]  
1
  • UniProtKB
Ion channel bindingdefinition[GO:0044325] silver  
1
  • Ortholog Compara
Phosphorelay sensor kinase activitydefinition[GO:0000155] silver  
1
  • InterPro 2 GO
Protein bindingdefinition[GO:0005515]  
4
  • IntAct
Protein heterodimerization activitydefinition[GO:0046982] silver  
1
  • Ortholog Compara
Protein kinase bindingdefinition[GO:0019901] silver  
1
  • Ortholog Compara
GO biological process 
Cellular response to calcium iondefinition[GO:0071277] silver  
1
  • Ortholog Compara
Myoblast fusiondefinition[GO:0007520]  
1
  • PINC
Phosphorelay signal transduction systemdefinition[GO:0000160] silver  
1
  • InterPro 2 GO
Potassium ion transmembrane transportdefinition[GO:0071805]  
1
  • UniProtKB
Potassium ion transportdefinition[GO:0006813]  
1
  • PINC
Regulation of cell proliferationdefinition[GO:0042127]  
1
  • UniProtKB
Regulation of ion transmembrane transportdefinition[GO:0034765]  
1
  • UniProtKB KW
Regulation of membrane potentialdefinition[GO:0042391]  
1
  • RefGenome
Signal transduction by protein phosphorylationdefinition[GO:0023014]  
1
  • InterPro 2 GO
Startle responsedefinition[GO:0001964] silver  
1
  • Ortholog Compara
Pathways 
According to Reactome, this protein belongs to the following pathway:
Voltage gated Potassium channels  R-HSA-1296072  
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Potassium transport  definition   [KW-0633]
Transport  definition   [KW-0813]
Molecular function 
Ion channel  definition   [KW-0407]
Potassium channel  definition   [KW-0631]
Voltage-gated channel  definition   [KW-0851]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: KCNH1
GenomeRNAi: 3756
PRO: PR:O95259
Chemistry
GuidetoPHARMACOLOGY: 570