SNAPIN - SNARE-associated protein Snapin - human protein (Function)
 
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SNAPIN »  SNARE-associated protein Snapin
 
Protein also known as:  Biogenesis of lysosome-related organelles complex 1 subunit 7 (BLOC-1 subunit 7).
Gene name:  SNAPIN
Family name: SNAPIN
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 37 1
GENE REF ISO

Function

 show evidences
Overview 
Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking. May modulate a step between vesicle priming, fusion and calcium-dependent neurotransmitter release through its ability to potentiate the interaction of synaptotagmin with the SNAREs and the plasma-membrane-associated protein SNAP25. Its phosphorylation state influences exocytotic protein interactions and may regulate synaptic vesicle exocytosis. May also have a role in the mechanisms of SNARE-mediated membrane fusion in non-neuronal cells.  
1
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the synaptosomal vesicle fusion pore (svf-pore) family  1.F.1.1.1  
GO molecular function 
Protein bindingdefinition[GO:0005515]  
7
  • IPIIntAct
  • IPIUniProtKB
SNARE bindingdefinition[GO:0000149]  
1
  • IDAMGI
GO biological process 
Anterograde axon cargo transportdefinition[GO:0008089]  
  • ISSOrtholog Curator
Anterograde synaptic vesicle transportdefinition[GO:0048490]  
  • ISSOrtholog Curator
Intracellular protein transportdefinition[GO:0006886] silver  
  • IEAInterPro 2 GO
Melanosome organizationdefinition[GO:0032438]  
1
  • NASUniProtKB
Neuron projection developmentdefinition[GO:0031175]  
  • ISSOrtholog Curator
Neurotransmitter secretiondefinition[GO:0007269]  
1
  • TASPINC
Synaptic vesicle exocytosisdefinition[GO:0016079]  
1
  • IDAMGI
Synaptic vesicle fusion to presynaptic membranedefinition[GO:0031629] silver  
  • IEAOrtholog Compara
Synaptic vesicle maturationdefinition[GO:0016188] silver  
  • IEAOrtholog Compara
Terminal button organizationdefinition[GO:0072553] silver  
  • IEAOrtholog Compara
Viral processdefinition[GO:0016032]  
  • IEAUniProtKB KW
Pathways 
According to Reactome, this protein belongs to the following pathway:
Membrane Trafficking  REACT_11123  
 

Keywords

Biological process 
Exocytosis  definition   [KW-0268]
Host-virus interaction  definition   [KW-0945]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: SNAPAP
GenomeRNAi: 23557
PRO: PR:O95295