ABCB11 - Bile salt export pump - human protein (Function)
 
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Protein
Gene
References

 
ABCB11 »  Bile salt export pump
 
Protein also known as:  ATP-binding cassette sub-family B member 11.
Gene name:  ABCB11
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

 show evidences
Overview 
Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes.  
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the atp-binding cassette (abc) superfamily  3.A.1.201.2  
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
ATPase activity, coupled to transmembrane movement of substancesdefinition[GO:0042626] silver  
  • IBARefGenome
Bile acid-exporting ATPase activitydefinition[GO:0015432]  
1
  • TASPINC
Canalicular bile acid transmembrane transporter activitydefinition[GO:0015126] silver  
  • IBARefGenome
Sodium-exporting ATPase activity, phosphorylative mechanismdefinition[GO:0008554]  
1
  • TASPINC
Transporter activitydefinition[GO:0005215]  
1
  • TASPINC
GO biological process 
ATP catabolic processdefinition[GO:0006200]  
1
  • TASGOC
  • IBARefGenome
Canalicular bile acid transportdefinition[GO:0015722] silver  
  • IBARefGenome
Cation transportdefinition[GO:0006812]  
1
  • TASGOC
Ion transmembrane transportdefinition[GO:0034220]  
1
  • TASGOC
  • IBARefGenome
Lipid transportdefinition[GO:0006869]  
1
  • TASGOC
  • IBARefGenome
Metal ion transportdefinition[GO:0030001]  
1
  • TASGOC
Monovalent inorganic cation transportdefinition[GO:0015672]  
1
  • TASGOC
Sodium ion transmembrane transportdefinition[GO:0035725]  
1
  • TASGOC
Transmembrane transportdefinition[GO:0055085] silver  
  • IBARefGenome
Transportdefinition[GO:0006810]  
1
  • TASPINC
Pathways 
According to KEGG, this protein belongs to the following pathways:
ABC transporters  hsa02010+8647  
Bile secretion  hsa04976+8647  
According to Reactome, this protein belongs to the following pathway:
Metabolism  REACT_111217  
 

Biophysicochemical properties

Kinetic parameters
KM 30.4 uM for taurocholate
Vmax 232 pmol/min/mg enzyme for taurocholate transport

Keywords

Biological process 
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ABCB11
GenomeRNAi: 8647
PRO: PR:O95342