ABCB11 - Bile salt export pump - human protein (Function)
 
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Protein
Gene
References

 
ABCB11 »  Bile salt export pump
 
Protein also known as:  ATP-binding cassette sub-family B member 11.
Gene name:  ABCB11
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes.  
1
  • UniProtKB
According to TCDB this is a transporter from family:
the atp-binding cassette (abc) superfamily  3.A.1.201.2  
GO molecular function 
ATP bindingdefinition[GO:0005524]  
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  • UniProtKB KW
Bile acid-exporting ATPase activitydefinition[GO:0015432]  
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  • PINC
Canalicular bile acid transmembrane transporter activitydefinition[GO:0015126]  
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  • RefGenome
Sodium-exporting ATPase activity, phosphorylative mechanismdefinition[GO:0008554]  
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  • PINC
Transporter activitydefinition[GO:0005215]  
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  • PINC
GO biological process 
Canalicular bile acid transportdefinition[GO:0015722]  
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  • RefGenome
Sodium ion transmembrane transportdefinition[GO:0035725]  
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  • GOC
Transportdefinition[GO:0006810]  
1
  • PINC
Pathways 
According to KEGG, this protein belongs to the following pathways:
ABC transporters  hsa02010+8647  
Bile secretion  hsa04976+8647  
According to Reactome, this protein belongs to the following pathways:
Defective ABCB11 causes progressive familial intrahepatic cholestasis 2 and benign recurrent intrahepatic cholestasis 2  R-HSA-5678520  
Recycling of bile acids and salts  R-HSA-159418  
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol  R-HSA-193368  
 

Biophysicochemical properties

Kinetic parameters
KM 30.4 uM for taurocholate
Vmax 232 pmol/min/mg enzyme for taurocholate transport

Keywords

Biological process 
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: ABCB11
GenomeRNAi: 8647
PRO: PR:O95342
Chemistry
GuidetoPHARMACOLOGY: 778