MAP3K6 - Mitogen-activated protein kinase kinase kinase 6 - human protein (Function)
 
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MAP3K6 »  Mitogen-activated protein kinase kinase kinase 6   [ EC 2.7.11.25 ]
 
Protein also known as:  Apoptosis signal-regulating kinase 2.
Gene name:  MAP3K6
Entry whose protein(s) existence is based on evidence at protein level
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1 28 3
GENE REF ISO

Function

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Overview 
Component of a protein kinase signal transduction cascade. Activates the JNK, but not ERK or p38 kinase pathways.  
2
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • IDAUniProtKB
Magnesium ion bindingdefinition[GO:0000287]  
1
  • IDAUniProtKB
MAP kinase kinase kinase activitydefinition[GO:0004709]  
1
  • IDAUniProtKB
GO biological process 
Activation of JUN kinase activitydefinition[GO:0007257]  
1
  • TASPINC
Activation of MAPKK activitydefinition[GO:0000186]  
1
  • IDAGOC
Protein phosphorylationdefinition[GO:0006468]  
1
  • IDAUniProtKB
Signal transductiondefinition[GO:0007165]  
1
  • TASPINC
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.25: ATP + a protein ADP + a phosphoprotein.  
  • CuratedUniProtKB
It requires the following cofactor
Magnesium (By similarity).  
  • CuratedUniProtKB
It is regulated in the following manner
Activated by phosphorylation on Thr-806. Catalytically active only when complexed with MAP3K5, with MAP3K5 supporting the stability and the active configuration of MAP3K6 and MAP3K6 activating MAP3K5 by direct phosphorylation.  
1
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathway:
MAPK signaling pathway  hsa04010+9064  
 

Keywords

Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GenomeRNAi: 9064
PRO: PR:O95382
Chemistry
GuidetoPHARMACOLOGY: 2081