GDF11 - Growth/differentiation factor 11 - human protein (Function)
 
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GDF11 »  Growth/differentiation factor 11  (GDF-11)
 
Protein also known as:  Bone morphogenetic protein 11 (BMP-11).
Gene name:  GDF11
Family name: TGF-beta
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Secreted signal that acts globally to specify positional identity along the anterior/posterior axis during development. Play critical roles in patterning both mesodermal and neural tissues and in establishing the skeletal pattern.  
1
  • UniProtKB
GO molecular function 
Cytokine activitydefinition[GO:0005125]  
1
  • RefGenome
Growth factor activitydefinition[GO:0008083]  
1
  • UniProtKB KW
Transforming growth factor beta receptor bindingdefinition[GO:0005160]  
1
  • RefGenome
GO biological process 
Camera-type eye morphogenesisdefinition[GO:0048593] silver  
1
  • Ortholog Compara
Cell developmentdefinition[GO:0048468]  
1
  • RefGenome
Cell maturationdefinition[GO:0048469] silver  
1
  • Ortholog Compara
Growthdefinition[GO:0040007] silver  
1
  • InterPro 2 GO
Mesoderm developmentdefinition[GO:0007498]  
1
  • UniProtKB
Metanephros developmentdefinition[GO:0001656] silver  
1
  • Ortholog Compara
Negative regulation of cell differentiationdefinition[GO:0045596] silver  
1
  • Ortholog Compara
Negative regulation of cell proliferationdefinition[GO:0008285] silver  
1
  • Ortholog Compara
Nervous system developmentdefinition[GO:0007399]  
1
  • UniProtKB
Palate developmentdefinition[GO:0060021] silver  
1
  • Ortholog Compara
Pancreas developmentdefinition[GO:0031016] silver  
1
  • Ortholog Compara
Positive regulation of pathway-restricted SMAD protein phosphorylationdefinition[GO:0010862]  
1
  • RefGenome
Regulation of apoptotic processdefinition[GO:0042981]  
1
  • RefGenome
Regulation of MAPK cascadedefinition[GO:0043408]  
1
  • RefGenome
Skeletal system developmentdefinition[GO:0001501]  
1
  • UniProtKB
SMAD protein signal transductiondefinition[GO:0060395]  
1
  • RefGenome
Spinal cord anterior/posterior patterningdefinition[GO:0021512] silver  
1
  • Ortholog Compara
Ureteric bud developmentdefinition[GO:0001657] silver  
1
  • Ortholog Compara
 

Keywords

Molecular function 
Cytokine  definition   [KW-0202]
Growth factor  definition   [KW-0339]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: GDF11
GenomeRNAi: 10220
PRO: PR:O95390