PIGN - GPI ethanolamine phosphate transferase 1 - human protein (Function)
 
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Protein
Gene
References

 
PIGN »  GPI ethanolamine phosphate transferase 1   [ EC 2.-.-.- ]
 
Protein also known as:  Phosphatidylinositol-glycan biosynthesis class N protein (PIG-N).
Gene name:  PIGN
Family name: PIGG/PIGN/PIGO » PIGN
Entry whose protein(s) existence is based on evidence at protein level
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1 18 1
GENE REF ISO

Function

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Overview 
Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor (By similarity). May act as suppressor of replication stress and chromosome missegregation.  
1
  • CuratedUniProtKB
GO molecular function 
Transferase activitydefinition[GO:0016740]  
  • IEAUniProtKB KW
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Glycosylphosphatidylinositol(GPI)-anchor biosynthesis  hsa00563+23556  
Metabolic pathways  hsa01100+23556  
According to Reactome, this protein belongs to the following pathway:
Synthesis of glycosylphosphatidylinositol (GPI)  REACT_952  
 

Keywords

Biological process 
GPI-anchor biosynthesis  definition   [KW-0337]
Molecular function 
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 23556
PRO: PR:O95427