SLC34A2 - Sodium-dependent phosphate transport protein 2B - human protein (Function)
 
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SLC34A2 »  Sodium-dependent phosphate transport protein 2B  (Sodium-phosphate transport protein 2B)
 
Protein also known as:  Na(+)-dependent phosphate cotransporter 2B.
Gene name:  SLC34A2
Family name: SLC34A transporter
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 37 2
GENE REF ISO

Function

 show evidences
Overview 
May be involved in actively transporting phosphate into cells via Na(+) cotransport. It may be the main phosphate transport protein in the intestinal brush border membrane. May have a role in the synthesis of surfactant in lungs' alveoli.  
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the phosphate:na(+) symporter (pnas) family  2.A.58.1.4  
GO molecular function 
Phosphate ion bindingdefinition[GO:0042301]  
1
  • IDAUniProtKB
Protein domain specific bindingdefinition[GO:0019904] silver  
  • IEAOrtholog Compara
Sodium ion bindingdefinition[GO:0031402]  
1
  • IDAUniProtKB
Sodium-dependent phosphate transmembrane transporter activitydefinition[GO:0015321]  
3
  • IDAUniProtKB
Sodium:phosphate symporter activitydefinition[GO:0005436]  
3
  • IDAUniProtKB
GO biological process 
Agingdefinition[GO:0007568] silver  
  • IEAOrtholog Compara
Cellular phosphate ion homeostasisdefinition[GO:0030643]  
1
  • IDAUniProtKB
In utero embryonic developmentdefinition[GO:0001701] silver  
  • IEAOrtholog Compara
Ion transmembrane transportdefinition[GO:0034220]  
3
  • IDAGOC
Phosphate ion transmembrane transportdefinition[GO:0035435]  
3
  • IDAGOC
Phosphate ion transportdefinition[GO:0006817]  
3
  • IDAUniProtKB
Response to estradioldefinition[GO:0032355] silver  
  • IEAOrtholog Compara
Response to estrogendefinition[GO:0043627]  
1
  • IEPUniProtKB
Response to fructosedefinition[GO:0009750] silver  
  • IEAOrtholog Compara
Sodium ion transmembrane transportdefinition[GO:0035725]  
3
  • IDAGOC
Pathways 
According to KEGG, this protein belongs to the following pathway:
Mineral absorption  hsa04978+10568  
According to Reactome, this protein belongs to the following pathway:
Transmembrane transport of small molecules  REACT_15518  
 

Biophysicochemical properties

Dependence
pH Optimum pH is 6.6.

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Sodium transport  definition   [KW-0739]
Symport  definition   [KW-0769]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: SLC34A2
GenomeRNAi: 10568
PRO: PR:O95436