ADAMTS2 - A disintegrin and metalloproteinase with thrombospondin motifs 2 - human protein (Function)
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ADAMTS2 »  A disintegrin and metalloproteinase with thrombospondin motifs 2   [ EC ]  (ADAMTS-2)
Protein also known as:  Procollagen I/II amino propeptide-processing enzyme.
Gene name:  ADAMTS2
Entry whose protein(s) existence is based on evidence at protein level
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1 27 2


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Cleaves the propeptides of type I and II collagen prior to fibril assembly. Does not act on type III collagen. May also play a role in development that is independent of its role in collagen biosynthesis.  
  • CuratedUniProtKB
GO molecular function 
Metalloendopeptidase activitydefinition[GO:0004222] silver  
  • IEAInterPro 2 GO
Metallopeptidase activitydefinition[GO:0008237]  
Zinc ion bindingdefinition[GO:0008270] silver  
  • IEAInterPro 2 GO
GO biological process 
Collagen catabolic processdefinition[GO:0030574]  
  • IEAUniProtKB KW
Collagen fibril organizationdefinition[GO:0030199] silver  
  • IEAOrtholog Compara
Lung developmentdefinition[GO:0030324] silver  
  • IEAOrtholog Compara
Protein processingdefinition[GO:0016485] silver  
  • IEAOrtholog Compara
Skin developmentdefinition[GO:0043588] silver  
  • IEAOrtholog Compara
Spermatogenesisdefinition[GO:0007283] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC Cleaves the N-propeptide of collagen chain alpha-1(I) at Pro-|-Gln and of alpha-1(II) and alpha-2(I) at Ala-|-Gln.  
  • CuratedUniProtKB
It requires the following cofactor
Binds 1 zinc ion per subunit (By similarity).  
  • CuratedUniProtKB
More information is available from:
According to Reactome, this protein belongs to the following pathways:
Extracellular matrix organization  REACT_118779  
Metabolism of proteins  REACT_17015  
Has sometimes been referred to as ADAMTS3.  
  • CuratedUniProtKB


Biological process 
Collagen degradation  definition   [KW-0177]
Molecular function 
Hydrolase  definition   [KW-0378]
Metalloprotease  definition   [KW-0482]
Protease  definition   [KW-0645]
Technical term 
Reference proteome  definition   [KW-1185]

Further external links

GeneWiki: ADAMTS2
GenomeRNAi: 9509
PRO: PR:O95450