ABCA1 - ATP-binding cassette sub-family A member 1 - human protein (Function)
 
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Protein
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ABCA1 »  ATP-binding cassette sub-family A member 1
 
Protein also known as:  Cholesterol efflux regulatory protein.
Gene name:  ABCA1
Family name: ABC transporter » ABCA
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 412 1
GENE REF ISO

Function

 show evidences
Overview 
CAMP-dependent and sulfonylurea-sensitive anion transporter. Key gatekeeper influencing intracellular cholesterol transport.  
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the atp-binding cassette (abc) superfamily  3.A.1.211.14  
GO molecular function 
Anion transmembrane transporter activitydefinition[GO:0008509]  
  • ISSOrtholog Curator
Apolipoprotein A-I bindingdefinition[GO:0034186]  
2
  • IPIBHF-UCL
Apolipoprotein A-I receptor activitydefinition[GO:0034188]  
1
  • IDABHF-UCL
Apolipoprotein bindingdefinition[GO:0034185]  
1
  • IPIBHF-UCL
ATP bindingdefinition[GO:0005524]  
1
  • IDABHF-UCL
ATPase activitydefinition[GO:0016887] silver  
  • IEAInterPro 2 GO
ATPase bindingdefinition[GO:0051117]  
1
  • IPIBHF-UCL
Cholesterol bindingdefinition[GO:0015485]  
1
  • ICBHF-UCL
Cholesterol transporter activitydefinition[GO:0017127]  
1
  • IDABHF-UCL
Phospholipid bindingdefinition[GO:0005543]  
1
  • ICBHF-UCL
Phospholipid transporter activitydefinition[GO:0005548]  
1
  • IDABHF-UCL
Protein bindingdefinition[GO:0005515]  
4
  • IPIIntAct
  • IPIBHF-UCL
Receptor bindingdefinition[GO:0005102]  
1
  • IPIBHF-UCL
Small GTPase bindingdefinition[GO:0031267]  
1
  • IPIBHF-UCL
Syntaxin bindingdefinition[GO:0019905]  
1
  • IPIBHF-UCL
GO biological process 
Apolipoprotein A-I-mediated signaling pathwaydefinition[GO:0038027]  
1
  • IDAGOC
ATP catabolic processdefinition[GO:0006200]  
  • IEAInterPro 2 GO
Cellular response to cholesteroldefinition[GO:0071397] silver  
  • IEAOrtholog Compara
Cellular response to lipopolysaccharidedefinition[GO:0071222] silver  
  • IEAOrtholog Compara
Cellular response to retinoic aciddefinition[GO:0071300] silver  
  • IEAOrtholog Compara
Cholesterol effluxdefinition[GO:0033344]  
4
  • IDABHF-UCL
Cholesterol homeostasisdefinition[GO:0042632]  
1
  • IDABHF-UCL
Cholesterol metabolic processdefinition[GO:0008203]  
1
  • IDABHF-UCL
Endosomal transportdefinition[GO:0016197]  
1
  • IDABHF-UCL
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
1
  • IMPBHF-UCL
High-density lipoprotein particle assemblydefinition[GO:0034380]  
2
  • IMPBHF-UCL
Interleukin-1 beta secretiondefinition[GO:0050702]  
1
  • IMPBHF-UCL
Intracellular cholesterol transportdefinition[GO:0032367]  
1
  • IMPBHF-UCL
Lysosome organizationdefinition[GO:0007040]  
1
  • IDABHF-UCL
Negative regulation of cholesterol storagedefinition[GO:0010887]  
1
  • TASBHF-UCL
Negative regulation of macrophage derived foam cell differentiationdefinition[GO:0010745]  
1
  • TASBHF-UCL
Peptide secretiondefinition[GO:0002790] silver  
  • IEAOrtholog Compara
Phagocytosis, engulfmentdefinition[GO:0006911] silver  
  • IEAOrtholog Compara
Phospholipid effluxdefinition[GO:0033700]  
3
  • IMPBHF-UCL
Phospholipid homeostasisdefinition[GO:0055091]  
1
  • IMPBHF-UCL
Phospholipid translocationdefinition[GO:0045332] silver  
  • IEAOrtholog Compara
Platelet dense granule organizationdefinition[GO:0060155]  
1
  • IMPBHF-UCL
Positive regulation of cAMP biosynthetic processdefinition[GO:0030819]  
1
  • IMPBHF-UCL
Positive regulation of cholesterol effluxdefinition[GO:0010875] silver  
  • IEAOrtholog Compara
Protein lipidationdefinition[GO:0006497] silver  
  • IEAOrtholog Compara
Regulation of Cdc42 protein signal transductiondefinition[GO:0032489]  
1
  • IMPBHF-UCL
Response to drugdefinition[GO:0042493] silver  
  • IEAOrtholog Compara
Response to laminar fluid shear stressdefinition[GO:0034616]  
1
  • IEPBHF-UCL
Response to low-density lipoprotein particledefinition[GO:0055098]  
1
  • IEPBHF-UCL
Response to nutrientdefinition[GO:0007584] silver  
  • IEAOrtholog Compara
Reverse cholesterol transportdefinition[GO:0043691]  
1
  • IMPBHF-UCL
Pathways 
According to KEGG, this protein belongs to the following pathways:
ABC transporters  hsa02010+19  
Fat digestion and absorption  hsa04975+19  
According to Reactome, this protein belongs to the following pathways:
HDL-mediated lipid transport  REACT_13621  
PPARA activates gene expression  REACT_116145  
 

Keywords

Biological process 
Cholesterol metabolism  definition   [KW-0153]
Lipid metabolism  definition   [KW-0443]
Steroid metabolism  definition   [KW-0753]
Sterol metabolism  definition   [KW-1207]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: ABCA1
GenomeRNAi: 19
PRO: PR:O95477
Chemistry
GuidetoPHARMACOLOGY: 756