H6PD - GDH/6PGL endoplasmic bifunctional protein - human protein (Function)
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H6PD »  GDH/6PGL endoplasmic bifunctional protein
Gene name:  H6PD
Family names: In the N-terminal section Glucose-6-phosphate dehydrogenase
In the C-terminal section Glucosamine/galactosamine-6-phosphate isomerase » 6-phosphogluconolactonase
Entry whose protein(s) existence is based on evidence at protein level
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Oxidizes glucose-6-phosphate and glucose, as well as other hexose-6-phosphates.  
  • CuratedUniProtKB
GO molecular function 
6-phosphogluconolactonase activitydefinition[GO:0017057]  
  • IEAEC 2 GO
Carbohydrate bindingdefinition[GO:0030246] silver  
  • IEAOrtholog Compara
Glucose 1-dehydrogenase [NAD(P)] activitydefinition[GO:0047936]  
  • IEAEC 2 GO
Glucose-6-phosphate dehydrogenase activitydefinition[GO:0004345] silver  
  • IEAOrtholog Compara
NADP bindingdefinition[GO:0050661] silver  
  • IEAOrtholog Compara
GO biological process 
Pentose-phosphate shuntdefinition[GO:0006098] silver  
  • IEAOrtholog Compara
Response to alcoholdefinition[GO:0097305] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reactions
D-glucose 6-phosphate + NAD(P)(+) D-glucono-1,5-lactone 6-phosphate + NAD(P)H.  
  • CuratedUniProtKB
EC Beta-D-glucose + NAD(P)(+) D-glucono-1,5-lactone + NAD(P)H.  
  • CuratedUniProtKB
EC 6-phospho-D-glucono-1,5-lactone + H(2)O 6-phospho-D-gluconate.  
  • CuratedUniProtKB
According to KEGG, this protein belongs to the following pathways:
Metabolic pathways  hsa01100+9563  
Pentose phosphate pathway  hsa00030+9563  
More information is available from:


Biological process 
Carbohydrate metabolism  definition   [KW-0119]
Glucose metabolism  definition   [KW-0313]
Molecular function 
Hydrolase  definition   [KW-0378]
Oxidoreductase  definition   [KW-0560]
Technical term 
Multifunctional enzyme  definition   [KW-0511]
Reference proteome  definition   [KW-1185]

Further external links

Enzyme and pathway databases
SABIO-RK: O95479
GeneWiki: H6PD
GenomeRNAi: 9563
PRO: PR:O95479