ACSL3 - Long-chain-fatty-acid--CoA ligase 3 - human protein (Function)
 
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ACSL3 »  Long-chain-fatty-acid--CoA ligase 3   [ EC 6.2.1.3 ]
 
Protein also known as:  Long-chain acyl-CoA synthetase 3 (LACS 3).
Gene name:  ACSL3
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 35 1
GENE REF ISO

Function

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Overview 
Acyl-CoA synthetases (ACSL) activates long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. ACSL3 mediates hepatic lipogenesis (By similarity). Preferentially uses myristate, laurate, arachidonate and eicosapentaenoate as substrates (By similarity). Has mainly an anabolic role in energy metabolism. Required for the incorporation of fatty acids into phosphatidylcholine, the major phospholipid located on the surface of VLDL (very low density lipoproteins).  
2
  • UniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • UniProtKB KW
Long-chain fatty acid-CoA ligase activitydefinition[GO:0004467]  
1
  • UniProtKB
Protein domain specific bindingdefinition[GO:0019904]  
1
  • UniProtKB
Protein kinase bindingdefinition[GO:0019901]  
1
  • UniProtKB
GO biological process 
Brain developmentdefinition[GO:0007420] silver  
1
  • Ortholog Compara
Fatty acid biosynthetic processdefinition[GO:0006633] silver  
1
  • Ortholog Compara
Long-chain fatty acid importdefinition[GO:0044539]  
1
  • UniProtKB
Long-chain fatty acid metabolic processdefinition[GO:0001676]  
3
  • GOC
  • Ortholog Compara
  • EC 2 GO
Positive regulation of Golgi to plasma membrane protein transportdefinition[GO:0042998]  
1
  • UniProtKB
Positive regulation of phosphatidylcholine biosynthetic processdefinition[GO:2001247]  
1
  • UniProtKB
Positive regulation of secretiondefinition[GO:0051047]  
1
  • UniProtKB
Response to nutrientdefinition[GO:0007584] silver  
1
  • Ortholog Compara
Response to organic cyclic compounddefinition[GO:0014070] silver  
1
  • Ortholog Compara
Very-low-density lipoprotein particle assemblydefinition[GO:0034379]  
1
  • UniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 6.2.1.3: ATP + a long-chain fatty acid + CoA AMP + diphosphate + an acyl-CoA.  
1
  • UniProtKB
It requires the following cofactor
 Mg(2+)  
1
  • UniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Adipocytokine signaling pathway  hsa04920+2181  
Fatty acid metabolism  hsa00071+2181  
Metabolic pathways  hsa01100+2181  
Peroxisome  hsa04146+2181  
PPAR signaling pathway  hsa03320+2181  
According to Reactome, this protein belongs to the following pathway:
Synthesis of very long-chain fatty acyl-CoAs  REACT_380  
 
More information is available from:
 

Keywords

Biological process 
Fatty acid metabolism  definition   [KW-0276]
Lipid metabolism  definition   [KW-0443]
Molecular function 
Ligase  definition   [KW-0436]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ACSL3
GenomeRNAi: 2181
PRO: PR:O95573