ADCY5 - Adenylate cyclase type 5 - human protein (Function)
 
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ADCY5 »  Adenylate cyclase type 5   [ EC 4.6.1.1 ]
 
Protein also known as:  ATP pyrophosphate-lyase 5.
Gene name:  ADCY5
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
This is a membrane-bound, calcium-inhibitable adenylyl cyclase.  
  • CuratedUniProtKB
GO molecular function 
Adenylate cyclase activitydefinition[GO:0004016]  
  • IEAEC 2 GO
Adenylate cyclase bindingdefinition[GO:0008179]  
  • ISSOrtholog Curator
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Protein heterodimerization activitydefinition[GO:0046982]  
  • ISSOrtholog Curator
GO biological process 
Adenosine receptor signaling pathwaydefinition[GO:0001973] silver  
  • IEAOrtholog Compara
Adenylate cyclase-activating dopamine receptor signaling pathwaydefinition[GO:0007191] silver  
  • IEAOrtholog Compara
Adenylate cyclase-inhibiting dopamine receptor signaling pathwaydefinition[GO:0007195] silver  
  • IEAOrtholog Compara
cAMP biosynthetic processdefinition[GO:0006171]  
  • IEAUniProtKB KW
Intracellular signal transductiondefinition[GO:0035556] silver  
  • IEAInterPro 2 GO
Locomotory behaviordefinition[GO:0007626] silver  
  • IEAOrtholog Compara
Neuromuscular process controlling balancedefinition[GO:0050885] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 4.6.1.1: ATP 3',5'-cyclic AMP + diphosphate.  
  • CuratedUniProtKB
It requires the following cofactor
Binds 2 magnesium ions per subunit (By similarity).  
  • CuratedUniProtKB
It is regulated in the following manner
Inhibition by calcium in the submicromolar concentration range (By similarity). Phosphorylation by RAF1 results in its activation.  
1
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Bile secretion  hsa04976+111  
Chemokine signaling pathway  hsa04062+111  
Cholinergic synapse  hsa04725+111  
Dilated cardiomyopathy  hsa05414+111  
Dopaminergic synapse  hsa04728+111  
GABAergic synapse  hsa04727+111  
Gap junction  hsa04540+111  
Gastric acid secretion  hsa04971+111  
Glutamatergic synapse  hsa04724+111  
GnRH signaling pathway  hsa04912+111  
HTLV-I infection  hsa05166+111  
Melanogenesis  hsa04916+111  
Oocyte meiosis  hsa04114+111  
Pancreatic secretion  hsa04972+111  
Progesterone-mediated oocyte maturation  hsa04914+111  
Purine metabolism  hsa00230+111  
Salivary secretion  hsa04970+111  
Vascular smooth muscle contraction  hsa04270+111  
According to Reactome, this protein belongs to the following pathways:
Adenylate cyclase activating pathway  REACT_15312  
Adenylate cyclase inhibitory pathway  REACT_15333  
Adrenaline,noradrenaline inhibits insulin secretion  REACT_18339  
G alpha (i) signalling events  REACT_19231  
G alpha (s) signalling events  REACT_19327  
G alpha (z) signalling events  REACT_19333  
Glucagon signaling in metabolic regulation  REACT_1665  
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion  REACT_18274  
PKA activation  REACT_15530  
PKA activation in glucagon signalling  REACT_1946  
Regulation of water balance by renal Aquaporins  REACT_24023  
 

Keywords

Biological process 
cAMP biosynthesis  definition   [KW-0115]
Molecular function 
Lyase  definition   [KW-0456]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: ADCY5
GenomeRNAi: 111
PRO: PR:O95622
Chemistry
GuidetoPHARMACOLOGY: 1282