ADCY5 - Adenylate cyclase type 5 - human protein (Function)
 
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Protein
Gene
References

 
ADCY5 »  Adenylate cyclase type 5   [ EC 4.6.1.1 ]
 
Protein also known as:  ATP pyrophosphate-lyase 5.
Gene name:  ADCY5
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling (PubMed15385642, PubMed26206488, PubMed24700542). Mediates signaling downstream of ADRB1 (PubMed24700542). Regulates the increase of free cytosolic Ca(2+) in response to increased blood glucose levels and contributes to the regulation of Ca(2+)-dependent insulin secretion (PubMed24740569).  
5
  • UniProtKB
GO molecular function 
Adenylate cyclase activitydefinition[GO:0004016]  
4
  • UniProtKB
  • RefGenome
Adenylate cyclase bindingdefinition[GO:0008179]  
1
  • Ortholog Curator
ATP bindingdefinition[GO:0005524]  
1
  • UniProtKB KW
Metal ion bindingdefinition[GO:0046872]  
1
  • UniProtKB KW
Protein heterodimerization activitydefinition[GO:0046982]  
1
  • Ortholog Curator
GO biological process 
Adenosine receptor signaling pathwaydefinition[GO:0001973] silver  
1
  • Ortholog Compara
Adenylate cyclase-activating dopamine receptor signaling pathwaydefinition[GO:0007191] silver  
1
  • Ortholog Compara
Adenylate cyclase-activating G-protein coupled receptor signaling pathwaydefinition[GO:0007189]  
1
  • UniProtKB
Adenylate cyclase-inhibiting dopamine receptor signaling pathwaydefinition[GO:0007195] silver  
1
  • Ortholog Compara
cAMP biosynthetic processdefinition[GO:0006171]  
4
  • UniProtKB
  • RefGenome
cAMP-mediated signalingdefinition[GO:0019933]  
1
  • RefGenome
Cellular response to forskolindefinition[GO:1904322]  
2
  • UniProtKB
Locomotory behaviordefinition[GO:0007626] silver  
1
  • Ortholog Compara
Neuromuscular process controlling balancedefinition[GO:0050885] silver  
1
  • Ortholog Compara
Positive regulation of cytosolic calcium ion concentrationdefinition[GO:0007204]  
1
  • UniProtKB
Regulation of insulin secretion involved in cellular response to glucose stimulusdefinition[GO:0061178]  
1
  • UniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 4.6.1.1: ATP 3',5'-cyclic AMP + diphosphate.  
4
  • UniProtKB
It requires the following cofactor
 Mg(2+) : Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).  
3
  • UniProtKB
It is regulated in the following manner
Activated by forskolin (PubMed:24700542). Activated by GNAS. Activity is further increased by interaction with the G-protein beta and gamma subunit complex formed by GNB1 and GNG2 (PubMed26206488). Is not activated by calmodulin. Inhibited by adenosine and ATP analogs. Inhibited by calcium ions, already at micromolar concentrations (By similarity). Phosphorylation by RAF1 results in its activation (PubMed15385642).  
4
  • UniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Bile secretion  hsa04976+111  
Chemokine signaling pathway  hsa04062+111  
Cholinergic synapse  hsa04725+111  
Dilated cardiomyopathy  hsa05414+111  
Dopaminergic synapse  hsa04728+111  
GABAergic synapse  hsa04727+111  
Gap junction  hsa04540+111  
Gastric acid secretion  hsa04971+111  
Glutamatergic synapse  hsa04724+111  
GnRH signaling pathway  hsa04912+111  
HTLV-I infection  hsa05166+111  
Melanogenesis  hsa04916+111  
Oocyte meiosis  hsa04114+111  
Pancreatic secretion  hsa04972+111  
Progesterone-mediated oocyte maturation  hsa04914+111  
Purine metabolism  hsa00230+111  
Salivary secretion  hsa04970+111  
Vascular smooth muscle contraction  hsa04270+111  
According to Reactome, this protein belongs to the following pathways:
Adenylate cyclase activating pathway  R-HSA-170660  
Adenylate cyclase inhibitory pathway  R-HSA-170670  
Adrenaline,noradrenaline inhibits insulin secretion  R-HSA-400042  
G alpha (i) signalling events  R-HSA-418594  
G alpha (s) signalling events  R-HSA-418555  
G alpha (z) signalling events  R-HSA-418597  
Glucagon signaling in metabolic regulation  R-HSA-163359  
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion  R-HSA-381676  
Hedgehog 'off' state  R-HSA-5610787  
PKA activation  R-HSA-163615  
PKA activation in glucagon signalling  R-HSA-164378  
Vasopressin regulates renal water homeostasis via Aquaporins  R-HSA-432040  
 

Keywords

Biological process 
cAMP biosynthesis  definition   [KW-0115]
Molecular function 
Lyase  definition   [KW-0456]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: ADCY5
GenomeRNAi: 111
PRO: PR:O95622
Chemistry
GuidetoPHARMACOLOGY: 1282