NTN1 - Netrin-1 - human protein (Function)
 
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Protein
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NTN1 »  Netrin-1
 
Protein also known as:  Epididymis tissue protein Li 131P.
Gene name:  NTN1
Entry whose protein(s) existence is based on evidence at protein level
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1 66 1
GENE REF ISO

Function

 show evidences
Overview 
Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serve as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in tumorigenesis by regulating apoptosis.  
1
  • CuratedUniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
2
  • IPIUniProtKB
GO biological process 
Anterior/posterior axon guidancedefinition[GO:0033564] silver  
  • IEAOrtholog Compara
Apoptotic processdefinition[GO:0006915]  
  • IEAUniProtKB KW
Establishment of nucleus localizationdefinition[GO:0040023] silver  
  • IEAOrtholog Compara
Inner ear morphogenesisdefinition[GO:0042472] silver  
  • IEAOrtholog Compara
Mammary gland duct morphogenesisdefinition[GO:0060603] silver  
  • IEAOrtholog Compara
Negative regulation of axon extensiondefinition[GO:0030517] silver  
  • IEAOrtholog Compara
Neuron migrationdefinition[GO:0001764] silver  
  • IEAOrtholog Compara
Positive regulation of axon extensiondefinition[GO:0045773] silver  
  • IEAOrtholog Compara
Positive regulation of cell proliferationdefinition[GO:0008284] silver  
  • IEAOrtholog Compara
Regulation of cell migrationdefinition[GO:0030334] silver  
  • IEAOrtholog Compara
Single organismal cell-cell adhesiondefinition[GO:0016337] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathway:
Axon guidance  hsa04360+9423  
According to Reactome, this protein belongs to the following pathways:
Cell-Cell communication  REACT_111155  
Developmental Biology  REACT_111045  
 

Keywords

Biological process 
Apoptosis  definition   [KW-0053]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: NTN1
GenomeRNAi: 9423
PRO: PR:O95631