IL33 - Interleukin-33 - human protein (Function)
 
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IL33 »  Interleukin-33  (IL-33)
 
Protein also known as:  Nuclear factor from high endothelial venules (NF-HEV). Cleaved into:  Interleukin-33 (109-270); Interleukin-33 (95-270); Interleukin-33 (99-270).
Gene name:  IL33
Family name: IL-1
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells (PubMed16286016). Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as a chemoattractant for Th2 cells, and may function as an "alarmin", that amplifies immune responses during tissue injury (PubMed17853410, PubMed18836528).  
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  • CuratedUniProtKB
In quiescent endothelia the uncleaved form is constitutively and abundantly expressed, and acts as a chromatin-associated nuclear factor with transcriptional repressor properties, it may sequester nuclear NF-kappaB/RELA, lowering expression of its targets (PubMed21734074). This form is rapidely lost upon angiogenic or proinflammatory activation (PubMed18787100).  
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  • CuratedUniProtKB
GO molecular function 
Cytokine activitydefinition[GO:0005125]  
1
  • IDABHF-UCL
Protein bindingdefinition[GO:0005515]  
2
  • IPIIntAct
GO biological process 
Negative regulation of immunoglobulin secretiondefinition[GO:0051025] silver  
  • IEAOrtholog Compara
Negative regulation of interferon-gamma productiondefinition[GO:0032689] silver  
  • IEAOrtholog Compara
Negative regulation of leukocyte migrationdefinition[GO:0002686] silver  
  • IEAOrtholog Compara
Negative regulation of T-helper 1 type immune responsedefinition[GO:0002826] silver  
  • IEAOrtholog Compara
Positive regulation of chemokine secretiondefinition[GO:0090197]  
1
  • IDABHF-UCL
Positive regulation of immunoglobulin secretiondefinition[GO:0051024] silver  
  • IEAOrtholog Compara
Positive regulation of inflammatory responsedefinition[GO:0050729]  
1
  • ISSBHF-UCL
Positive regulation of interleukin-13 productiondefinition[GO:0032736] silver  
  • IEAOrtholog Compara
Positive regulation of interleukin-4 productiondefinition[GO:0032753] silver  
  • IEAOrtholog Compara
Positive regulation of interleukin-5 productiondefinition[GO:0032754] silver  
  • IEAOrtholog Compara
Positive regulation of interleukin-6 productiondefinition[GO:0032755] silver  
  • IEAOrtholog Compara
Positive regulation of macrophage activationdefinition[GO:0043032]  
1
  • IDABHF-UCL
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
1
  • ISSBHF-UCL
Positive regulation of type 2 immune responsedefinition[GO:0002830] silver  
  • IEAOrtholog Compara
Transcription, DNA-templateddefinition[GO:0006351]  
  • IEAUniProtKB KW
Pathways 
According to KEGG, this protein belongs to the following pathways:
Cytosolic DNA-sensing pathway  hsa04623+90865  
Influenza A  hsa05164+90865  
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Molecular function 
Cytokine  definition   [KW-0202]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 90865
PRO: PR:O95760