CER1 - Cerberus - human protein (Function)
 
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Protein
Gene
References

 
CER1 »  Cerberus
 
Protein also known as:  DAN domain family member 4.
Gene name:  CER1
Family name: DAN
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 23 1
GENE REF ISO

Function

 show evidences
Overview 
Cytokine that may play a role in anterior neural induction and somite formation during embryogenesis in part through a BMP-inhibitory mechanism. Can regulate Nodal signaling during gastrulation as well as the formation and patterning of the primitive streak (By similarity).  
  • CuratedUniProtKB
GO molecular function 
BMP bindingdefinition[GO:0036122]  
1
  • IDABHF-UCL
Cytokine activitydefinition[GO:0005125]  
  • IEAUniProtKB KW
Morphogen activitydefinition[GO:0016015]  
1
  • IDABHF-UCL
Protein homodimerization activitydefinition[GO:0042803]  
  • ISSOrtholog Curator
GO biological process 
Anterior/posterior axis specificationdefinition[GO:0009948]  
1
  • ISSBHF-UCL
Anterior/posterior pattern specificationdefinition[GO:0009952]  
1
  • ISSBHF-UCL
Bone mineralizationdefinition[GO:0030282]  
1
  • IMPBHF-UCL
Cell migration involved in gastrulationdefinition[GO:0042074]  
1
  • ISSBHF-UCL
Cellular response to BMP stimulusdefinition[GO:0071773]  
1
  • ISSBHF-UCL
Determination of dorsal identitydefinition[GO:0048263]  
1
  • IMPBHF-UCL
Gastrulationdefinition[GO:0007369]  
1
  • ISSBHF-UCL
Growth plate cartilage chondrocyte proliferationdefinition[GO:0003419]  
1
  • ISSBHF-UCL
Negative regulation of activin receptor signaling pathwaydefinition[GO:0032926]  
1
  • IDABHF-UCL
  • ISSOrtholog Curator
Negative regulation of BMP signaling pathwaydefinition[GO:0030514]  
1
  • ISSBHF-UCL
Negative regulation of cell proliferationdefinition[GO:0008285]  
1
  • ISSBHF-UCL
Negative regulation of mesoderm developmentdefinition[GO:2000381]  
1
  • IMPBHF-UCL
  • ISSOrtholog Curator
Not  Negative regulation of Wnt signaling pathwaydefinition[GO:0030178]  
  • ISSOrtholog Curator
Nervous system developmentdefinition[GO:0007399]  
1
  • IMPBHF-UCL
Sequestering of BMP in extracellular matrixdefinition[GO:0035582]  
1
  • IDABHF-UCL
  • ISSOrtholog Curator
Signal transduction involved in regulation of gene expressiondefinition[GO:0023019]  
1
  • ISSBHF-UCL
Ureteric bud developmentdefinition[GO:0001657]  
  • ISSOrtholog Curator
Pathways 
According to KEGG, this protein belongs to the following pathway:
Wnt signaling pathway  hsa04310+9350  
According to Reactome, this protein belongs to the following pathways:
Developmental Biology  REACT_111045  
Signal Transduction  REACT_111102  
 

Keywords

Molecular function 
Cytokine  definition   [KW-0202]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Cerberus_(protein)
GenomeRNAi: 9350
PRO: PR:O95813